WZYE_SHIFL
ID WZYE_SHIFL Reviewed; 450 AA.
AC Q83IX6;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Probable ECA polymerase {ECO:0000255|HAMAP-Rule:MF_01003};
GN Name=wzyE {ECO:0000255|HAMAP-Rule:MF_01003}; Synonyms=wecF;
GN OrderedLocusNames=SF3868, S3892;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Probably involved in the polymerization of enterobacterial
CC common antigen (ECA) trisaccharide repeat units. {ECO:0000255|HAMAP-
CC Rule:MF_01003}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC antigen biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01003}.
CC -!- SUBUNIT: Probably part of a complex composed of WzxE, WzyE and WzzE.
CC {ECO:0000255|HAMAP-Rule:MF_01003}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01003}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01003}.
CC -!- SIMILARITY: Belongs to the WzyE family. {ECO:0000255|HAMAP-
CC Rule:MF_01003}.
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DR EMBL; AE005674; AAN45305.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP18893.1; -; Genomic_DNA.
DR RefSeq; NP_709598.1; NC_004337.2.
DR RefSeq; WP_000055146.1; NZ_WPGW01000028.1.
DR AlphaFoldDB; Q83IX6; -.
DR STRING; 198214.SF3868; -.
DR EnsemblBacteria; AAN45305; AAN45305; SF3868.
DR EnsemblBacteria; AAP18893; AAP18893; S3892.
DR GeneID; 1025963; -.
DR KEGG; sfl:SF3868; -.
DR KEGG; sft:NCTC1_04180; -.
DR KEGG; sfx:S3892; -.
DR PATRIC; fig|198214.7.peg.4558; -.
DR HOGENOM; CLU_049711_0_0_6; -.
DR OMA; WLWPDRP; -.
DR OrthoDB; 614230at2; -.
DR UniPathway; UPA00566; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01003; WzyE; 1.
DR InterPro; IPR010691; WzyE.
DR Pfam; PF06899; WzyE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..450
FT /note="Probable ECA polymerase"
FT /id="PRO_0000208545"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
SQ SEQUENCE 450 AA; 51549 MW; 84870539BC21DB54 CRC64;
MSLLQFSGLF VVWLLCTLFI ATLTWFEFRR VRFNFNVFFS LLFLLTFFFG FPLTSVLVFR
FDVGVAPPEI LLQVLLSAGC FYAVYYVTYK TRLRKRVADV PRRPLFTMNR VETNLTWVIL
MGIALVSVGI FFMHNGFLLF RLNSYSQIFS SEVSGVALKR FFYFFIPAML VVYFLRQDSK
AWLFFLVSTV AFGLLTYMIV GGTRANIIIA FAIFLFIGII RGWISLWMLA AAGVLGIVGM
FWLALKRYGM NVSGDEAFYT FLYLTRDTFS PWENLALLLQ NYDNIDFQGL APIVRDFYVF
IPSWLWPGRP SMVLNSANYF TWEVLNNHSG LAISPTLIGS LVVMGGALFI PLGAIVVGLI
IKWFDWLYEL GNRETNRYKA AILHSFCFGA IFNMIVLARE GLDSFVSRVV FFIVVFGACL
MIAKLLYWLF ESAGLIHKRT KSSLRTQVEG
