CAND1_DICDI
ID CAND1_DICDI Reviewed; 1238 AA.
AC Q86KD1; Q554M6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Cullin-associated NEDD8-dissociated protein 1;
DE AltName: Full=Cullin-associated and neddylation-dissociated protein 1;
GN Name=cand1; ORFNames=DDB_G0274167;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3
CC ubiquitin ligase complexes that promotes the exchange of the substrate-
CC recognition F-box subunit in SCF complexes, thereby playing a key role
CC in the cellular repertoire of SCF complexes. Acts as a F-box protein
CC exchange factor (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CAND family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL69976.1; -; Genomic_DNA.
DR RefSeq; XP_644297.1; XM_639205.1.
DR AlphaFoldDB; Q86KD1; -.
DR SMR; Q86KD1; -.
DR STRING; 44689.DDB0234116; -.
DR PaxDb; Q86KD1; -.
DR EnsemblProtists; EAL69976; EAL69976; DDB_G0274167.
DR GeneID; 8619725; -.
DR KEGG; ddi:DDB_G0274167; -.
DR dictyBase; DDB_G0274167; cand1.
DR eggNOG; KOG1824; Eukaryota.
DR HOGENOM; CLU_007157_0_0_1; -.
DR InParanoid; Q86KD1; -.
DR OMA; MGGTQDD; -.
DR PhylomeDB; Q86KD1; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8951664; Neddylation.
DR Reactome; R-DDI-917937; Iron uptake and transport.
DR PRO; PR:Q86KD1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000151; C:ubiquitin ligase complex; ISS:dictyBase.
DR GO; GO:0043086; P:negative regulation of catalytic activity; ISS:dictyBase.
DR GO; GO:0016567; P:protein ubiquitination; ISS:dictyBase.
DR GO; GO:0010265; P:SCF complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039852; CAND1/CAND2.
DR InterPro; IPR013932; TATA-bd_TIP120.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR12696; PTHR12696; 1.
DR Pfam; PF08623; TIP120; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..1238
FT /note="Cullin-associated NEDD8-dissociated protein 1"
FT /id="PRO_0000327914"
FT REPEAT 41..78
FT /note="HEAT 1"
FT REPEAT 126..167
FT /note="HEAT 2"
FT REPEAT 171..208
FT /note="HEAT 3"
FT REPEAT 210..247
FT /note="HEAT 4"
FT REPEAT 251..292
FT /note="HEAT 5"
FT REPEAT 382..419
FT /note="HEAT 6"
FT REPEAT 432..469
FT /note="HEAT 7"
FT REPEAT 603..641
FT /note="HEAT 8"
FT REPEAT 646..683
FT /note="HEAT 9"
FT REPEAT 688..725
FT /note="HEAT 10"
FT REPEAT 853..890
FT /note="HEAT 11"
FT REPEAT 933..966
FT /note="HEAT 12"
FT REPEAT 967..1004
FT /note="HEAT 13"
FT REPEAT 1008..1045
FT /note="HEAT 14"
FT REGION 315..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..354
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1238 AA; 138935 MW; D2D5FC36F1ACD212 CRC64;
MSFFLGQILE KMGSIDKDIR FMATHDLANE LEKDTFKMDP TYENKIVTKL LALTADSANN
VQENVVKCLG LLIKRVKDSQ ATEIIDTLSK NILEESNKEE LVEISGIGLK TIITNLPSEG
SSISTLVIKN LVPKLLIGID SEKLKDKNEI KMSCLDILND LLQKYGSFMI GDLENIQKVV
LPKLNATRPA IRKRAILCLA NIAFPSPDNL FNSLLDYIIK SIEEAKKPDH ISTLIQAIGA
ICKSSGYRLG KYLPKVMPHV LNYCDNNKFE QNDELRENCL LCFEAIIEKC QKDVTPYIGE
IITLCTKYIK FDPNYSDDGE GEEDGDEEEE EMETSGDNDE EQEEEEEEED LSDDDDISWK
IRRSSCKTLC AIISTRPELL VELYQKVAPV LYNRFKEREE NVRLDIFTTF VLLLKQLNKK
LANPQAKEVL KQQVPKLVQS ISKSLIDKSI RTRVGAIALL KELVMIIPGS LTGQVSQIVN
GINLSLSEKN TNSNLKIEAL VLLKLLLINE PAQSFQSHIT SLSTHIVKCI NDSYYRIASE
ALRVCQEFVI VFNKIRSSTD CKPIISNLFA ANFVQLKAQD IDQEVKEAAI SSIGTIITLF
GNEIQSELQP CLSILLERLD NELTRVVTVK VLSRIINSSI NIDLSSILPS AIKLLSTFLR
KNNRVLKQSS LIALNDIVKV CPNLLPSSLL TGILTEMATL INESDLQITH LAFVFIQNLL
KNYSEKHQAA TLVNEKCIPP TLALLKSSLL QGVALESLLS LFATIVQLDE PGMKYEQLLT
LLFNTAADIK QPVTRQSFHS ISQCIAVITV NTTPALRKQT IHNLICNLSS VNEPLVLLSL
SCLGEIGRRI DIHENENLQE SVYKTFEANN EEIKQVAALC LGDIAVCSLQ SYLPFILEQI
KNQPKKQYLL LHTLRETIVK LSHTDEGIKT IHPFLQSILP LLFDNCVNEE EGTRNIVAEC
LGKLSMIEPN EIIPKLVEKI KSPSPLERST IVTSIKFSIM ENKEVVDQYL APNISQFLSL
LHDGDLIVRR SALLSLNYIA HNKPNLIRND LSVYLPILYN NAKIKPELIR EVDLGPFKHK
VDDGIEIRKT AFECMYTLLD TSIDKIDVAP FIVSLCDGLK DTQYDIKLLC HLMIIRLANS
NGAALLENIT LLLEPLRVIL MTKVNETAVK QQIERNEECI RSALRAVASI SRIPNSDSIV
KFEEFVKNTI RTTPLAAQFN SILSEDTMSN QDSMDTSN
