WZYE_YERPE
ID WZYE_YERPE Reviewed; 454 AA.
AC Q8ZAF1; Q0WAF4;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Probable ECA polymerase {ECO:0000255|HAMAP-Rule:MF_01003};
GN Name=wzyE {ECO:0000255|HAMAP-Rule:MF_01003}; Synonyms=wecF;
GN OrderedLocusNames=YPO3856, y0372, YP_3189;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Probably involved in the polymerization of enterobacterial
CC common antigen (ECA) trisaccharide repeat units. {ECO:0000255|HAMAP-
CC Rule:MF_01003}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC antigen biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01003}.
CC -!- SUBUNIT: Probably part of a complex composed of WzxE, WzyE and WzzE.
CC {ECO:0000255|HAMAP-Rule:MF_01003}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01003}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01003}.
CC -!- SIMILARITY: Belongs to the WzyE family. {ECO:0000255|HAMAP-
CC Rule:MF_01003}.
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DR EMBL; AL590842; CAL22443.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM83961.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS63357.1; -; Genomic_DNA.
DR PIR; AH0469; AH0469.
DR RefSeq; WP_002211978.1; NZ_WUCM01000073.1.
DR RefSeq; YP_002348734.1; NC_003143.1.
DR AlphaFoldDB; Q8ZAF1; -.
DR IntAct; Q8ZAF1; 3.
DR STRING; 214092.YPO3856; -.
DR PaxDb; Q8ZAF1; -.
DR DNASU; 1145319; -.
DR EnsemblBacteria; AAM83961; AAM83961; y0372.
DR EnsemblBacteria; AAS63357; AAS63357; YP_3189.
DR GeneID; 66843421; -.
DR KEGG; ype:YPO3856; -.
DR KEGG; ypk:y0372; -.
DR KEGG; ypm:YP_3189; -.
DR PATRIC; fig|214092.21.peg.4382; -.
DR eggNOG; ENOG502Z7MA; Bacteria.
DR HOGENOM; CLU_049711_0_0_6; -.
DR OMA; WLWPDRP; -.
DR UniPathway; UPA00566; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01003; WzyE; 1.
DR InterPro; IPR010691; WzyE.
DR Pfam; PF06899; WzyE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..454
FT /note="Probable ECA polymerase"
FT /id="PRO_0000208546"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
SQ SEQUENCE 454 AA; 51653 MW; 6860E50411716533 CRC64;
MTLGQFGGLF CIYLIAVIFI LTLTYQEFRR VKFNFNVLFS MLYLLTFYFG FPLTCMLVFQ
FGVAVVPVEY LLYAMLSATA FYGIYYVTYK TRLRQPRSQP RTPIFTMNRV ETNLTWVLLA
LVAVGTVGIF FMQNGFLLFK LDSYSKIFSS DVSGVALKRF FYFFIPAMLV VYFLKQDRRA
WFFFLASTVA FGILTYVIVG GTRANIIIAF SLFLFIGIVR GWITLWMLAA AGVFGIVGMF
WLALKRYGLD VNGAEAFYTF LYLTRDTFSP WENLGLLLQN YDKIDFQGLA PIVRDFYVFI
PSALWPERPD LVLNTANYFT WDVLDNHSGL AISPTLIGSL VVMGGVLFIP LGAIVVGLII
KWFDWLYEQG KAESNRYKAA ILQSFCFGAV FNIIVLAREG LDSFVSRVVF FCVIFGACLV
LAKLLYWLFD TAGLIKRQGI KSNRLSTPNA GNQL
