ID   WZZB_SHIDY              Reviewed;         325 AA.
AC   P95730;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Chain length determinant protein;
DE   AltName: Full=Polysaccharide antigen chain regulator;
GN   Name=wzzB; Synonyms=cld, rol;
OS   Shigella dysenteriae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=622;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=W30864;
RX   PubMed=9079931; DOI=10.1128/jb.179.7.2421-2425.1997;
RA   Klee S.R., Tzschaschel B.D., Timmis K.N., Guzman C.A.;
RT   "Influence of different rol gene products on the chain length of Shigella
RT   dysenteriae type 1 lipopolysaccharide O antigen expressed by Shigella
RT   flexneri carrier strains.";
RL   J. Bacteriol. 179:2421-2425(1997).
CC   -!- FUNCTION: Confers a modal distribution of chain length on the O-antigen
CC       component of lipopolysaccharide (LPS). Gives rise to a reduced number
CC       of short chain molecules and increases in numbers of longer molecules.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the WzzB/Cld/Rol family. {ECO:0000305}.
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DR   EMBL; Y07560; CAA68845.1; -; Genomic_DNA.
DR   RefSeq; WP_005021694.1; NZ_UAUQ01000007.1.
DR   AlphaFoldDB; P95730; -.
DR   SMR; P95730; -.
DR   UniPathway; UPA00030; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   Pfam; PF02706; Wzz; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Lipopolysaccharide biosynthesis;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..325
FT                   /note="Chain length determinant protein"
FT                   /id="PRO_0000065994"
FT   TOPO_DOM        1..31
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..294
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        316..325
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   325 AA;  36296 MW;  3B861D7A170D12E0 CRC64;
     MRVENNNVSG QNHDPEQIDL IDLLVQLWRG KMTIIISVIV AIALAIGYLA VAKEKWTSTA
     IVTQPDVGQI AGYNNAMNVI YGQATPKVSD LQETLIGRFS SAFSALAETL DNQEEPEKLT
     IEPSVKNQQL PLTVSYVGQT AEGAQMKLAQ YIQQVDDKVN QELEKDLKDN IALGRKNLQD
     SLRTQEVVAQ EQKDLRIRQI QEALQYANQA QVTKPQVQQT EDVTQDTLFL LGSEALESMI
     KHEATRPLVF SPSYYQTRQN LLDIENLKVD DLDIHAYRYV MKPTLPIRRD SPKKAITLIL
     AVLLGGMVGA GIVLGRNALR NYNAK