WZZE_SALTY
ID WZZE_SALTY Reviewed; 348 AA.
AC O33789; Q9L6R6;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=ECA polysaccharide chain length modulation protein {ECO:0000255|HAMAP-Rule:MF_02025};
GN Name=wzzE {ECO:0000255|HAMAP-Rule:MF_02025}; Synonyms=metN;
GN OrderedLocusNames=STM3919; ORFNames=STMD1.71;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RA Mouslim C., Cano D.A., Casadesus J.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Modulates the polysaccharide chain length of enterobacterial
CC common antigen (ECA). {ECO:0000255|HAMAP-Rule:MF_02025}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC antigen biosynthesis. {ECO:0000255|HAMAP-Rule:MF_02025}.
CC -!- SUBUNIT: Probably part of a complex composed of WzxE, WzyE and WzzE.
CC {ECO:0000255|HAMAP-Rule:MF_02025}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_02025}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_02025}.
CC -!- SIMILARITY: Belongs to the WzzB/Cld/Rol family. {ECO:0000255|HAMAP-
CC Rule:MF_02025}.
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DR EMBL; AJ002275; CAA05288.1; -; Genomic_DNA.
DR EMBL; AF233324; AAF33468.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22768.1; -; Genomic_DNA.
DR RefSeq; NP_462809.1; NC_003197.2.
DR RefSeq; WP_000193413.1; NC_003197.2.
DR AlphaFoldDB; O33789; -.
DR SMR; O33789; -.
DR STRING; 99287.STM3919; -.
DR PaxDb; O33789; -.
DR EnsemblBacteria; AAL22768; AAL22768; STM3919.
DR GeneID; 1255445; -.
DR KEGG; stm:STM3919; -.
DR PATRIC; fig|99287.12.peg.4140; -.
DR HOGENOM; CLU_060925_2_1_6; -.
DR OMA; GLCCTLW; -.
DR PhylomeDB; O33789; -.
DR BioCyc; SENT99287:STM3919-MON; -.
DR UniPathway; UPA00566; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR HAMAP; MF_02025; WzzE; 1.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR032895; WzzE.
DR Pfam; PF02706; Wzz; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..348
FT /note="ECA polysaccharide chain length modulation protein"
FT /id="PRO_0000065999"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02025"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02025"
FT CONFLICT 8..12
FT /note="ARAVS -> KHARD (in Ref. 1; CAA05288)"
FT /evidence="ECO:0000305"
FT CONFLICT 34..63
FT /note="IGIGLLFALIALAYTFFARQEWSATAITDR -> DRHWPAICPYRVSLYLFC
FT SSGVECDGDHRS (in Ref. 1; CAA05288)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="Missing (in Ref. 1; CAA05288)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="A -> R (in Ref. 1; CAA05288)"
FT /evidence="ECO:0000305"
FT CONFLICT 303..314
FT /note="QTYRYLRTPEEP -> SDLSLFAYAGRT (in Ref. 1; CAA05288)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 348 AA; 39461 MW; DC911233B5AE783A CRC64;
MTQPLPGARA VSAENELDIR GLFRTLWAGK FWIIGIGLLF ALIALAYTFF ARQEWSATAI
TDRPTVNMLG GYYSQQQFLR NLDIKTDPAS SDKPSVMDEA YKEFIMQLAS WDTRRDFWLQ
TDYYKQRMVG NSKADAAMLD ELINNIQFTP GDFTRAINDN VKLIAETAPD ANNLLRQYVA
FASQRAASHL NDELKGAWAA RTVQMKAQVK RQEEVAKAIY SRRVNSIEQA LKIAEQHNIS
RSATDVPADE LPDSELFLLG RPMLQARLEN LQAVGPAFDL DYFQNRAMLN TLNVGPTLDP
RFQTYRYLRT PEEPVKRDSP RRAFLMIMWG IVGALIGAGV ALTRRRTI
