W_HENDH
ID W_HENDH Reviewed; 448 AA.
AC P0C1C6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 23-FEB-2022, entry version 43.
DE RecName: Full=Protein W;
GN Name=P/V/C;
OS Hendra virus (isolate Horse/Autralia/Hendra/1994).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC Henipavirus.
OX NCBI_TaxID=928303;
OH NCBI_TaxID=9796; Equus caballus (Horse).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9402; Pteropus alecto (Black flying fox).
OH NCBI_TaxID=9403; Pteropus poliocephalus (Grey-headed flying fox).
OH NCBI_TaxID=94117; Pteropus scapulatus (Little red flying fox).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=11024125; DOI=10.1128/jvi.74.21.9972-9979.2000;
RA Wang L.-F., Yu M., Hansson E., Pritchard L.I., Shiell B., Michalski W.P.,
RA Eaton B.T.;
RT "The exceptionally large genome of Hendra virus: support for creation of a
RT new genus within the family Paramyxoviridae.";
RL J. Virol. 74:9972-9979(2000).
CC -!- RNA EDITING: Modified_positions=407 {ECO:0000250}; Note=Partially
CC edited. RNA editing at this position consists of an insertion of one or
CC two guanine nucleotides. The sequence displayed here is the W protein,
CC derived from the +2G edited RNA. The unedited RNA gives rise to the P
CC protein (AC O55778), the +1G edited RNA gives rise to the V protein (AC
CC O55777) (By similarity). {ECO:0000250};
CC -!- MISCELLANEOUS: The P/V/C gene has two overlapping open reading frames.
CC One encodes the P/V/W proteins and the other the C protein.
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DR EMBL; AF017149; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR PDB; 6BW1; X-ray; 2.20 A; C=409-448.
DR PDB; 6BW9; X-ray; 1.60 A; B=409-448.
DR PDB; 6BWA; X-ray; 2.20 A; B=409-448.
DR PDB; 6BWB; X-ray; 2.30 A; B=409-448.
DR PDBsum; 6BW1; -.
DR PDBsum; 6BW9; -.
DR PDBsum; 6BWA; -.
DR PDBsum; 6BWB; -.
DR SASBDB; P0C1C6; -.
DR SMR; P0C1C6; -.
DR IntAct; P0C1C6; 53.
DR PRIDE; P0C1C6; -.
DR Proteomes; UP000008771; Genome.
DR InterPro; IPR035430; Paramyxo_PNT.
DR InterPro; IPR025909; Soyouz_module.
DR Pfam; PF14320; Paramyxo_PNT; 1.
DR Pfam; PF14313; Soyouz_module; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Phosphoprotein; Reference proteome; RNA editing.
FT CHAIN 1..448
FT /note="Protein W"
FT /id="PRO_0000236016"
FT REGION 26..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 257
FT /note="Phosphoserine; by host"
FT /evidence="ECO:0000250"
FT MOD_RES 350
FT /note="Phosphoserine; by host"
FT /evidence="ECO:0000250"
FT TURN 427..430
FT /evidence="ECO:0007829|PDB:6BWB"
SQ SEQUENCE 448 AA; 49351 MW; D2324C5D500768D0 CRC64;
MDKLDLVNDG LDIIDFIQKN QKEIQKTYGR SSIQQPSTKD RTRAWEDFLQ STSGEHEQAE
GGMPKNDGGT EGRNVEDLSS VTSSDGTIGQ RVSNTRAWAE DPDDIQLDPM VTDVVYHDHG
GECTGHGPSS SPERGWSYHM SGTHDGNVRA VPDTKVLPNA PKTTVPEEVR EIDLIGLEDK
FASAGLNPAA VPFVPKNQST PTEEPPVIPE YYYGSGRRGD LSKSPPRGNV NLDSIKIYTS
DDEDENQLEY EDEFAKSSSE VVIDTTPEDN DSINQEEVVG DPSDQGLEHP FPLGKFPEKE
ETPDVRRKDS LMQDSCKRGG VPKRLPMLSE EFECSGSDDP IIQELEREGS HPGGSLRLRE
PPQSSGNSRN QPDRQLKTGD AASPGGVQRP GTPMPKSRIM PIKKGAQTRS LNMLGRKTCL
GRRVVQPGMF ADYPPTKKAR VLLRRMSN
