XAC1_TRYB2
ID XAC1_TRYB2 Reviewed; 117 AA.
AC Q57Y88; D6XKJ5;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=PBP1-interacting protein XAC1 {ECO:0000303|PubMed:32532821};
DE AltName: Full=EXpression ACtivator 1 {ECO:0000303|PubMed:32532821};
GN Name=XAC1 {ECO:0000303|PubMed:32532821};
GN ORFNames=Tb927.7.2780 {ECO:0000312|EMBL:AAX69420.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000312|Proteomes:UP000008524};
RN [1] {ECO:0000312|EMBL:AAZ12342.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000312|EMBL:AAZ12342.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [2] {ECO:0000312|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000312|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C.M., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [3] {ECO:0000305}
RP FUNCTION, IDENTIFICATION IN A COMPLEX WITH PBP1; LSM12 AND MKT1 OR MKT1L,
RP SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=427 {ECO:0000303|PubMed:32532821};
RX PubMed=32532821; DOI=10.1074/jbc.ra120.013306;
RA Melo do Nascimento L., Terrao M., Marucha K.K., Liu B., Egler F.,
RA Clayton C.;
RT "The RNA-associated proteins MKT1 and MKT1L form alternative PBP1-
RT containing complexes in Trypanosoma brucei.";
RL J. Biol. Chem. 295:10940-10955(2020).
CC -!- FUNCTION: Involved in post-transcriptional regulation of gene
CC expression. {ECO:0000269|PubMed:32532821}.
CC -!- SUBUNIT: Forms a complex composed of at least MKT1, PBP1, XAC1 and
CC LSM12 (PubMed:32532821). Forms a complex composed of at least MKT1L,
CC PBP1, XAC1 and LSM12 (PubMed:32532821). {ECO:0000269|PubMed:32532821}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32532821}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the bloodstream form (at protein
CC level). {ECO:0000269|PubMed:32532821}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in the bloodstream form
CC abolishes cell population growth. {ECO:0000269|PubMed:32532821}.
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DR EMBL; AC159408; AAX69420.1; -; Genomic_DNA.
DR EMBL; CP000070; AAZ12342.1; -; Genomic_DNA.
DR RefSeq; XP_845901.1; XM_840808.1.
DR AlphaFoldDB; Q57Y88; -.
DR PaxDb; Q57Y88; -.
DR GeneID; 3658491; -.
DR KEGG; tbr:Tb927.7.2780; -.
DR VEuPathDB; TriTrypDB:Tb927.7.2780; -.
DR InParanoid; Q57Y88; -.
DR OMA; HEELMDC; -.
DR Proteomes; UP000008524; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; IDA:GeneDB.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Translation regulation.
FT CHAIN 1..117
FT /note="PBP1-interacting protein XAC1"
FT /id="PRO_0000451928"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 117 AA; 12723 MW; EA39C3CE00ED6F65 CRC64;
MSKAPSQPAK KWMSARTLAK SEDATNRKSN TAAPASQPSQ QPASVMHERP TPPPPAPVQL
PQSVFFERQE AVDTLSNLYR NAQSVKKIET GPAAFEARDI SKVHEELMDC LRPAAAA
