ID   XACH_HALVD              Reviewed;         317 AA.
AC   D4GP36; L9VIH7;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Xylose/arabinose import permease protein XacH {ECO:0000305};
GN   Name=xacH {ECO:0000303|PubMed:31089701};
GN   Synonyms=tsgB7 {ECO:0000312|EMBL:ADE01289.1};
GN   OrderedLocusNames=HVO_B0035 {ECO:0000312|EMBL:ADE01289.1};
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OG   Plasmid pHV3.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
RN   [2]
RP   FUNCTION, SUBUNIT, AND INDUCTION.
RC   STRAIN=DS2 / DS70 / H26;
RX   PubMed=31089701; DOI=10.1093/femsle/fnz089;
RA   Johnsen U., Ortjohann M., Sutter J.M., Geweke S., Schoenheit P.;
RT   "Uptake of D-xylose and L-arabinose in Haloferax volcanii involves an ABC
RT   transporter of the CUT1 subfamily.";
RL   FEMS Microbiol. Lett. 366:0-0(2019).
CC   -!- FUNCTION: Part of the ABC transporter complex XacGHIJK involved in the
CC       uptake of xylose and arabinose (PubMed:31089701). Responsible for the
CC       translocation of the substrate across the membrane (Probable).
CC       {ECO:0000269|PubMed:31089701, ECO:0000305}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (XacJ and
CC       XacK), two transmembrane proteins (XacH and XacI) and a solute-binding
CC       protein (XacG). {ECO:0000305|PubMed:31089701}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Transcriptionally up-regulated by both L-arabinose and D-
CC       xylose via the pentose-specific regulator XacR.
CC       {ECO:0000269|PubMed:31089701}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; CP001953; ADE01289.1; -; Genomic_DNA.
DR   RefSeq; WP_004041120.1; NZ_AOHU01000021.1.
DR   AlphaFoldDB; D4GP36; -.
DR   SMR; D4GP36; -.
DR   STRING; 309800.C498_01585; -.
DR   TCDB; 3.A.1.1.56; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; ADE01289; ADE01289; HVO_B0035.
DR   GeneID; 8919131; -.
DR   KEGG; hvo:HVO_B0035; -.
DR   PATRIC; fig|309800.29.peg.302; -.
DR   eggNOG; arCOG00157; Archaea.
DR   HOGENOM; CLU_016047_0_0_2; -.
DR   OMA; IIATMQV; -.
DR   OrthoDB; 53481at2157; -.
DR   Proteomes; UP000008243; Plasmid pHV3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Plasmid; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..317
FT                   /note="Xylose/arabinose import permease protein XacH"
FT                   /id="PRO_0000449391"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   DOMAIN          94..309
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   317 AA;  34995 MW;  C00AAFDA46F6FA45 CRC64;
     MATHDNTEHV SDATDEAVGW ESKLRYFLNS DFVRSAPYWG IPFVLMSIAV YGGTGYNFAI
     SFTDYEGLGT PDYSTLDLEM YAQALSSDAF IAAAQNNLVL LVGFTTICLV LGLFLAILLD
     HGIRFSEKFQ TVYLLPMSLS FVVTAQLWLW MFNVESGILN LVVTTLGFNP VDWLGNPSIA
     LGAVILALIW QFSGYTMVVY LAGLQSIPDD QFEAARVDGA SITRTYLRII VPQLKEASVS
     AAVVLMVFAL KAFTFLYALV GRYRPPNGTD ILATLMVRRA FKFGEWAYSA AIATMLLIMA
     LGVIGPYLYY QYKQGGL