ID   XACI_HALVD              Reviewed;         309 AA.
AC   D4GP37; L9VI94;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Xylose/arabinose import permease protein XacI {ECO:0000305};
GN   Name=xacI {ECO:0000303|PubMed:31089701};
GN   Synonyms=tsgC7 {ECO:0000312|EMBL:ADE01611.1};
GN   OrderedLocusNames=HVO_B0036 {ECO:0000312|EMBL:ADE01611.1};
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OG   Plasmid pHV3.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
RN   [2]
RP   FUNCTION, SUBUNIT, AND INDUCTION.
RC   STRAIN=DS2 / DS70 / H26;
RX   PubMed=31089701; DOI=10.1093/femsle/fnz089;
RA   Johnsen U., Ortjohann M., Sutter J.M., Geweke S., Schoenheit P.;
RT   "Uptake of D-xylose and L-arabinose in Haloferax volcanii involves an ABC
RT   transporter of the CUT1 subfamily.";
RL   FEMS Microbiol. Lett. 366:0-0(2019).
CC   -!- FUNCTION: Part of the ABC transporter complex XacGHIJK involved in the
CC       uptake of xylose and arabinose (PubMed:31089701). Responsible for the
CC       translocation of the substrate across the membrane (Probable).
CC       {ECO:0000269|PubMed:31089701, ECO:0000305}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (XacJ and
CC       XacK), two transmembrane proteins (XacH and XacI) and a solute-binding
CC       protein (XacG). {ECO:0000305|PubMed:31089701}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Transcriptionally up-regulated by both L-arabinose and D-
CC       xylose via the pentose-specific regulator XacR.
CC       {ECO:0000269|PubMed:31089701}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; CP001953; ADE01611.1; -; Genomic_DNA.
DR   RefSeq; WP_004041119.1; NZ_AOHU01000021.1.
DR   AlphaFoldDB; D4GP37; -.
DR   SMR; D4GP37; -.
DR   STRING; 309800.C498_01580; -.
DR   TCDB; 3.A.1.1.56; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; ADE01611; ADE01611; HVO_B0036.
DR   GeneID; 8919031; -.
DR   KEGG; hvo:HVO_B0036; -.
DR   PATRIC; fig|309800.29.peg.301; -.
DR   eggNOG; arCOG00159; Archaea.
DR   HOGENOM; CLU_016047_1_2_2; -.
DR   OMA; EYAIFFR; -.
DR   OrthoDB; 46692at2157; -.
DR   Proteomes; UP000008243; Plasmid pHV3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Plasmid; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..309
FT                   /note="Xylose/arabinose import permease protein XacI"
FT                   /id="PRO_0000449392"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00441"
FT   DOMAIN          85..297
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   309 AA;  33669 MW;  E7529E6BCD082D42 CRC64;
     MSQSSSTGNF DVASLVEDVN LRRVAQYALV VFFLGFFLVP LETGIMTAIK TNESVARSLP
     FAPPVGEGFT LGNIQFALEQ LSGSFFNSLI MSIPATIGSV LFGSMAAYGL TMVNWRAQMG
     MLMLFVVGVF VPYQAVLVPL ARFWNNIFPL ARMIEPMVAS IPFFQGYHAE LVPLVITHIA
     YGIPICTILF RSYYQSLPNS LVEAGKIDGA SITKIYRRII LPISKPMFGV VFIYQFTQIY
     NEFLFAFTLV TGSDAPAAPV TLVLPAIGAS TSGINFGIRM SAAFLAAVPT LILYVAFAEQ
     FAKGLRTEA