ID   XACR_HALVD              Reviewed;         251 AA.
AC   D4GP42; L9VI90;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=HTH-type transcriptional regulator XacR {ECO:0000305};
DE   AltName: Full=Pentose-specific regulator XacR {ECO:0000303|PubMed:28854683};
GN   Name=xacR {ECO:0000303|PubMed:25141768};
GN   OrderedLocusNames=HVO_B0040 {ECO:0000312|EMBL:ADE01288.1};
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OG   Plasmid pHV3.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
RN   [2]
RP   FUNCTION IN XACABDEF REGULATION, SUBUNIT, AND DISRUPTION PHENOTYPE.
RX   PubMed=25141768; DOI=10.1111/1462-2920.12603;
RA   Johnsen U., Sutter J.M., Schulz A.C., Taestensen J.B., Schoenheit P.;
RT   "XacR - a novel transcriptional regulator of D-xylose and L-arabinose
RT   catabolism in the haloarchaeon Haloferax volcanii.";
RL   Environ. Microbiol. 17:1663-1676(2015).
RN   [3]
RP   FUNCTION IN XACC REGULATION.
RC   STRAIN=DS2 / DS70 / H26;
RX   PubMed=28854683; DOI=10.1093/femsle/fnx140;
RA   Sutter J.M., Johnsen U., Schoenheit P.;
RT   "Characterization of a pentonolactonase involved in D-xylose and L-
RT   arabinose catabolism in the haloarchaeon Haloferax volcanii.";
RL   FEMS Microbiol. Lett. 364:0-0(2017).
RN   [4]
RP   FUNCTION IN XACGHIJK REGULATION.
RX   PubMed=31089701; DOI=10.1093/femsle/fnz089;
RA   Johnsen U., Ortjohann M., Sutter J.M., Geweke S., Schoenheit P.;
RT   "Uptake of D-xylose and L-arabinose in Haloferax volcanii involves an ABC
RT   transporter of the CUT1 subfamily.";
RL   FEMS Microbiol. Lett. 366:0-0(2019).
CC   -!- FUNCTION: Essential for D-xylose and L-arabinose catabolism. Activates
CC       the expression of genes involved in D-xylose and L-arabinose
CC       degradation (xacABCDEF) and represses its own synthesis
CC       (PubMed:25141768, PubMed:28854683). Also up-regulates the expression of
CC       the genes encoding the ABC transporter complex XacGHIJK
CC       (PubMed:31089701). {ECO:0000269|PubMed:25141768,
CC       ECO:0000269|PubMed:28854683, ECO:0000269|PubMed:31089701}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:25141768}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant loses its ability to grow on both
CC       D-xylose and L-arabinose. {ECO:0000269|PubMed:25141768}.
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DR   EMBL; CP001953; ADE01288.1; -; Genomic_DNA.
DR   RefSeq; WP_004041114.1; NZ_AOHU01000021.1.
DR   AlphaFoldDB; D4GP42; -.
DR   SMR; D4GP42; -.
DR   EnsemblBacteria; ADE01288; ADE01288; HVO_B0040.
DR   GeneID; 8919114; -.
DR   KEGG; hvo:HVO_B0040; -.
DR   PATRIC; fig|309800.29.peg.296; -.
DR   eggNOG; arCOG02798; Archaea.
DR   HOGENOM; CLU_062618_6_1_2; -.
DR   OMA; IGGHRQA; -.
DR   OrthoDB; 82473at2157; -.
DR   Proteomes; UP000008243; Plasmid pHV3.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Plasmid; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..251
FT                   /note="HTH-type transcriptional regulator XacR"
FT                   /id="PRO_0000449388"
FT   DOMAIN          7..66
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DOMAIN          81..251
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT   DNA_BIND        28..47
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ   SEQUENCE   251 AA;  27184 MW;  E71ADC1DB30A9FBA CRC64;
     MDAKHPVRTT EKTLALVEEL MQKGPCGVTE LAGDLDMGKS AVHNHLTTLQ KHGYVLKDGD
     DYRVGLKFLE VGGHSRKSME VYQVAEPEVK SLAADTGELA NLLVEEQGMG VYLMRAKGDD
     AVDLDTYAGL RTNLHTTALG KAILANLPES RVDEIIERHG LEQKTPKSIG TRQELFQVLE
     GVRERGYAID DGERLEGLRC LAAPIKSSSG EVLGAISVSA PASRVSDEDL HGALPERVLS
     AANVVELNIN Y