XAGE2_HUMAN
ID XAGE2_HUMAN Reviewed; 111 AA.
AC Q96GT9; Q5HYR4;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=X antigen family member 2;
DE Short=XAGE-2;
DE AltName: Full=Cancer/testis antigen 12.2;
DE Short=CT12.2;
DE AltName: Full=G antigen family D member 3;
GN Name=XAGE2; Synonyms=GAGED3, XAGE2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=11992404; DOI=10.1002/ijc.10371;
RA Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J.,
RA van Muijen G.N.P.;
RT "The XAGE family of cancer/testis-associated genes: alignment and
RT expression profile in normal tissues, melanoma lesions and Ewing's
RT sarcoma.";
RL Int. J. Cancer 99:361-369(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=10197611;
RA Brinkmann U., Vasmatzis G., Lee B., Pastan I.;
RT "Novel genes in the PAGE and GAGE family of tumor antigens found by
RT homology walking in the dbEST database.";
RL Cancer Res. 59:1445-1448(1999).
CC -!- INTERACTION:
CC Q96GT9; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-750167, EBI-10172181;
CC Q96GT9; Q96IK5: GMCL1; NbExp=5; IntAct=EBI-750167, EBI-2548508;
CC Q96GT9; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-750167, EBI-745707;
CC Q96GT9; Q9NYB0: TERF2IP; NbExp=2; IntAct=EBI-750167, EBI-750109;
CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
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DR EMBL; AJ318891; CAC88125.1; -; Genomic_DNA.
DR EMBL; AJ318892; CAC88125.1; JOINED; Genomic_DNA.
DR EMBL; AJ318880; CAC83007.1; -; mRNA.
DR EMBL; BX293536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL953874; CAI41681.1; -; Genomic_DNA.
DR EMBL; BC009232; AAH09232.1; -; mRNA.
DR EMBL; BC066311; AAH66311.1; -; mRNA.
DR CCDS; CCDS59525.1; -.
DR RefSeq; NP_570133.1; NM_130777.2.
DR RefSeq; XP_011529138.1; XM_011530836.2.
DR AlphaFoldDB; Q96GT9; -.
DR BioGRID; 114881; 14.
DR IntAct; Q96GT9; 11.
DR STRING; 9606.ENSP00000286049; -.
DR iPTMnet; Q96GT9; -.
DR PhosphoSitePlus; Q96GT9; -.
DR BioMuta; XAGE2; -.
DR DMDM; 21759127; -.
DR jPOST; Q96GT9; -.
DR MassIVE; Q96GT9; -.
DR MaxQB; Q96GT9; -.
DR PaxDb; Q96GT9; -.
DR PeptideAtlas; Q96GT9; -.
DR PRIDE; Q96GT9; -.
DR ProteomicsDB; 76665; -.
DR Antibodypedia; 79627; 95 antibodies from 17 providers.
DR DNASU; 9502; -.
DR Ensembl; ENST00000286049.3; ENSP00000286049.2; ENSG00000155622.7.
DR GeneID; 9502; -.
DR KEGG; hsa:9502; -.
DR MANE-Select; ENST00000286049.3; ENSP00000286049.2; NM_130777.3; NP_570133.1.
DR UCSC; uc004dqe.4; human.
DR CTD; 9502; -.
DR GeneCards; XAGE2; -.
DR HGNC; HGNC:4112; XAGE2.
DR HPA; ENSG00000155622; Tissue enriched (placenta).
DR MIM; 300416; gene.
DR neXtProt; NX_Q96GT9; -.
DR OpenTargets; ENSG00000155622; -.
DR PharmGKB; PA28527; -.
DR VEuPathDB; HostDB:ENSG00000155622; -.
DR eggNOG; ENOG502TF3A; Eukaryota.
DR GeneTree; ENSGT00940000153097; -.
DR HOGENOM; CLU_150116_2_1_1; -.
DR InParanoid; Q96GT9; -.
DR OMA; DPTPDQK; -.
DR OrthoDB; 542090at2759; -.
DR PhylomeDB; Q96GT9; -.
DR TreeFam; TF340669; -.
DR PathwayCommons; Q96GT9; -.
DR SignaLink; Q96GT9; -.
DR BioGRID-ORCS; 9502; 8 hits in 609 CRISPR screens.
DR GenomeRNAi; 9502; -.
DR Pharos; Q96GT9; Tbio.
DR PRO; PR:Q96GT9; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q96GT9; protein.
DR Bgee; ENSG00000155622; Expressed in placenta and 49 other tissues.
DR ExpressionAtlas; Q96GT9; baseline and differential.
DR Genevisible; Q96GT9; HS.
DR InterPro; IPR031320; GAGE.
DR InterPro; IPR008625; GAGE_fam.
DR PANTHER; PTHR14047; PTHR14047; 1.
DR Pfam; PF05831; GAGE; 1.
DR SMART; SM01379; GAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..111
FT /note="X antigen family member 2"
FT /id="PRO_0000148350"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 111 AA; 12354 MW; 38C93332C5BA0E14 CRC64;
MSWRGRSTYR PRPRRSLQPP ELIGAMLEPT DEEPKEEKPP TKSRNPTPDQ KREDDQGAAE
IQVPDLEADL QELCQTKTGD GCEGGTDVKG KILPKAEHFK MPEAGEGKSQ V
