ID   XAGE5_HUMAN             Reviewed;         108 AA.
AC   Q8WWM1; Q5JS81;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=X antigen family member 5;
DE            Short=XAGE-5;
DE   AltName: Full=Cancer/testis antigen 12.5;
DE            Short=CT12.5;
DE   AltName: Full=G antigen family D member 5;
GN   Name=XAGE5; Synonyms=GAGED5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11992404; DOI=10.1002/ijc.10371;
RA   Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J.,
RA   van Muijen G.N.P.;
RT   "The XAGE family of cancer/testis-associated genes: alignment and
RT   expression profile in normal tissues, melanoma lesions and Ewing's
RT   sarcoma.";
RL   Int. J. Cancer 99:361-369(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
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DR   EMBL; AJ318894; CAC83015.1; -; Genomic_DNA.
DR   EMBL; AL445236; CAI41618.1; -; Genomic_DNA.
DR   EMBL; BC069129; AAH69129.1; -; mRNA.
DR   CCDS; CCDS14346.1; -.
DR   RefSeq; NP_570131.1; NM_130775.2.
DR   RefSeq; XP_016884809.1; XM_017029320.1.
DR   AlphaFoldDB; Q8WWM1; -.
DR   STRING; 9606.ENSP00000342240; -.
DR   BioMuta; XAGE5; -.
DR   DMDM; 27805770; -.
DR   MassIVE; Q8WWM1; -.
DR   PaxDb; Q8WWM1; -.
DR   PeptideAtlas; Q8WWM1; -.
DR   PRIDE; Q8WWM1; -.
DR   ProteomicsDB; 74905; -.
DR   Antibodypedia; 54446; 4 antibodies from 4 providers.
DR   DNASU; 170627; -.
DR   Ensembl; ENST00000351072.5; ENSP00000342240.1; ENSG00000171405.13.
DR   Ensembl; ENST00000375501.2; ENSP00000364651.1; ENSG00000171405.13.
DR   GeneID; 170627; -.
DR   KEGG; hsa:170627; -.
DR   MANE-Select; ENST00000375501.2; ENSP00000364651.1; NM_001386970.1; NP_001373899.1.
DR   UCSC; uc064zio.1; human.
DR   CTD; 170627; -.
DR   GeneCards; XAGE5; -.
DR   HGNC; HGNC:30930; XAGE5.
DR   HPA; ENSG00000171405; Tissue enriched (testis).
DR   neXtProt; NX_Q8WWM1; -.
DR   PharmGKB; PA134961730; -.
DR   VEuPathDB; HostDB:ENSG00000171405; -.
DR   eggNOG; ENOG502TF3A; Eukaryota.
DR   GeneTree; ENSGT00940000153097; -.
DR   HOGENOM; CLU_150116_2_1_1; -.
DR   InParanoid; Q8WWM1; -.
DR   OMA; KSEQCKM; -.
DR   OrthoDB; 1551004at2759; -.
DR   PhylomeDB; Q8WWM1; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; Q8WWM1; -.
DR   BioGRID-ORCS; 170627; 7 hits in 615 CRISPR screens.
DR   GenomeRNAi; 170627; -.
DR   Pharos; Q8WWM1; Tdark.
DR   PRO; PR:Q8WWM1; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q8WWM1; protein.
DR   Bgee; ENSG00000171405; Expressed in testis and 16 other tissues.
DR   ExpressionAtlas; Q8WWM1; baseline and differential.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..108
FT                   /note="X antigen family member 5"
FT                   /id="PRO_0000148352"
FT   REGION          20..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   108 AA;  12077 MW;  E3CD91E5C9241628 CRC64;
     MSWRGRRYRP RRCLRLAQLV GPMLEPSVPE PQQEEPPTES QDHTPGQKRE DDQGAAEIQV
     PNLEADLQEL SQSKTGDECG DSPDVQGKIL PKSEQFKMPE GGEGKPQL