XANC_ASPFU
ID XANC_ASPFU Reviewed; 318 AA.
AC A4DA05;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Xanthocillin biosynthesis cluster transcription factor xanC {ECO:0000303|PubMed:29844112};
DE AltName: Full=Xanthocillin biosynthesis cluster protein C {ECO:0000303|PubMed:29844112};
GN Name=xanC {ECO:0000303|PubMed:29844112}; ORFNames=AFUA_5G02655;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=29844112; DOI=10.1128/mbio.00785-18;
RA Lim F.Y., Won T.H., Raffa N., Baccile J.A., Wisecaver J., Rokas A.,
RA Schroeder F.C., Keller N.P.;
RT "Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus
RT fumigatus.";
RL MBio 9:0-0(2018).
CC -!- FUNCTION: Transcription regulator that specifically up-regulates the
CC gene cluster that mediates the biosynthesis of the isocyanide
CC xanthocillin and its derivatives. {ECO:0000269|PubMed:29844112}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- INDUCTION: Expressed during copper starvation via the regulation of
CC both aceA and macA transcription factors.
CC {ECO:0000269|PubMed:29844112}.
CC -!- DISRUPTION PHENOTYPE: Virtually eliminates the production of all
CC pathway metabolites, including fumiformamide, melanocin E, melanocin F,
CC but also the sulfated xanthocillin derivative BU-4704 and xanthocillin
CC X monomethyl ether. {ECO:0000269|PubMed:29844112}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; AAHF01000011; EBA27255.1; -; Genomic_DNA.
DR RefSeq; XP_001481490.1; XM_001481440.1.
DR AlphaFoldDB; A4DA05; -.
DR SMR; A4DA05; -.
DR EnsemblFungi; EBA27255; EBA27255; AFUA_5G02655.
DR GeneID; 5077152; -.
DR KEGG; afm:AFUA_5G02655; -.
DR VEuPathDB; FungiDB:Afu5g02655; -.
DR eggNOG; ENOG502RNU7; Eukaryota.
DR HOGENOM; CLU_075842_0_0_1; -.
DR InParanoid; A4DA05; -.
DR OMA; YREMIGT; -.
DR OrthoDB; 1504908at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..318
FT /note="Xanthocillin biosynthesis cluster transcription
FT factor xanC"
FT /id="PRO_0000445296"
FT DOMAIN 20..52
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 25..40
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 41..48
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 71..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 318 AA; 34387 MW; 47F3D185E7EDA1B8 CRC64;
MHSQTTKDEQ SKDDSSNEKQ DAIERRRLQN RLSQRNHRRK IRDRIAKLQE RVIASELRAV
ATLNGWDQAS PPAASMMESK PQGDFDSNPL ASVSEDPAIS NPPQRNVSSN LCRSCCSLLN
QMPSSSSLPS PTSPLPFDLG LTNGVDSTNS SPSTLLNSSP SSSQLSPFSL DTSLSMTGLQ
SQNEFSFPPY PDPPGSQQYP HCPQYYVATE ASLPHIMQRL GSATSHPKAI ILIPHGHGYA
PAPFTGANAA DSTGLRSALN GNLNLQNPGR HCLRPDRSAK SSDLGTSGDW MTAPSSTPFC
PLHPSQSSSL DNYQSMML
