ID   XANP_ECOL6              Reviewed;         463 AA.
AC   P0AGN0; P27432;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Xanthine permease XanP {ECO:0000250|UniProtKB:P0AGM9};
GN   Name=xanP; OrderedLocusNames=c4479;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Specific, proton motive force-dependent high-affinity
CC       transporter for xanthine. {ECO:0000250|UniProtKB:P0AGM9}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + xanthine(in) = H(+)(out) + xanthine(out);
CC         Xref=Rhea:RHEA:29663, ChEBI:CHEBI:15378, ChEBI:CHEBI:17712;
CC         Evidence={ECO:0000250|UniProtKB:P0AGM9};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0AGM9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN82915.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN82915.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001295238.1; NC_004431.1.
DR   AlphaFoldDB; P0AGN0; -.
DR   SMR; P0AGN0; -.
DR   STRING; 199310.c4479; -.
DR   EnsemblBacteria; AAN82915; AAN82915; c4479.
DR   GeneID; 66672450; -.
DR   KEGG; ecc:c4479; -.
DR   eggNOG; COG2233; Bacteria.
DR   HOGENOM; CLU_017959_8_0_6; -.
DR   OMA; RKSAPFF; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   TIGRFAMs; TIGR00801; ncs2; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..463
FT                   /note="Xanthine permease XanP"
FT                   /id="PRO_0000165971"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   463 AA;  48868 MW;  868718559103456E CRC64;
     MSVSTLESEN AQPVAQTQNS ELIYRLEDRP PLPQTLFAAC QHLLAMFVAV ITPALLICQA
     LGLPAQDTQH IISMSLFASG VASIIQIKAW GPVGSGLLSI QGTSFNFVAP LIMGGTALKT
     GGADVPTMMA ALFGTLMLAS CTEMVISRVL HLARRIITPL VSGVVVMIIG LSLIQVGLTS
     IGGGYAAMSD NTFGAPKNLL LAGVVLALII LLNRQRNPYL RVASLVIAMA AGYALAWFMG
     MLPESNEPMT QELIMVPTPL YYGLGIEWSL LLPLMLVFMI TSLETIGDIT ATSDVSEQPV
     SGPLYMKRLK GGVLANGLNS FVSAVFNTFP NSCFGQNNGV IQLTGVASRY VGFVVALMLI
     VLGLFPAVSG FVQHIPEPVL GGATLVMFGT IAASGVRIVS REPLNRRAIL IIALSLAVGL
     GVSQQPLILQ FAPEWLKNLL SSGIAAGGIT AIVLNLIFPP EKQ