XANQ_ECOL6
ID XANQ_ECOL6 Reviewed; 466 AA.
AC P67445; Q46815;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Xanthine permease XanQ {ECO:0000250|UniProtKB:P67444};
GN Name=xanQ; OrderedLocusNames=c3460;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Specific, proton motive force-dependent high-affinity
CC transporter for xanthine. {ECO:0000250|UniProtKB:P67444}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + xanthine(in) = H(+)(out) + xanthine(out);
CC Xref=Rhea:RHEA:29663, ChEBI:CHEBI:15378, ChEBI:CHEBI:17712;
CC Evidence={ECO:0000250|UniProtKB:P67444};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P67444}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN81905.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014075; AAN81905.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001280192.1; NC_004431.1.
DR AlphaFoldDB; P67445; -.
DR SMR; P67445; -.
DR STRING; 199310.c3460; -.
DR EnsemblBacteria; AAN81905; AAN81905; c3460.
DR KEGG; ecc:c3460; -.
DR eggNOG; COG2233; Bacteria.
DR HOGENOM; CLU_017959_8_0_6; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR InterPro; IPR029938; XanQ.
DR PANTHER; PTHR42810:SF5; PTHR42810:SF5; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR TIGRFAMs; TIGR00801; ncs2; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..466
FT /note="Xanthine permease XanQ"
FT /id="PRO_0000165966"
FT TOPO_DOM 1..25
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..55
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..120
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..180
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..258
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..342
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 385..425
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 447..466
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P67444"
SQ SEQUENCE 466 AA; 49108 MW; 95EAFB06FEEE9175 CRC64;
MSDINHAGSD LIFELEDRPP FHQALVGAIT HLLAIFVPMV TPALIVGAAL QLSAETTAYL
VSMAMIASGI GTWLQVNRYG IVGSGLLSIQ SVNFSFVTVM IALGSSMKSD GFHEELIMSS
LLGVSFVGAF LVVGSSFILP YLRRVITPTV SGIVVLMIGL SLIKVGIIDF GGGFAAKSSG
TFGNYEHLGV GLLVLIVVIG FNCCRSPLLR MGGIAIGLCV GYIASLCLGM VDFSSMRNLP
LITIPHPFKY GFSFSFHQFL VVGTIYLLSV LEAVGDITAT AMVSRRPIQG EEYQSRLKGG
VLADGLVSVI ASAVGSLPLT TFAQNNGVIQ MTGVASRYVG RTIAVMLVIL GLFPMIGGFF
TTIPSAVLGG AMTLMFSMIA IAGIRIIITN GLKRRETLIV ATSLGLGLGV SYDPEIFKIL
PASIYVLVEN PICAGGLTAI LLNIILPGGY RQENVLPGIT SAEEMD
