CAND2_MOUSE
ID CAND2_MOUSE Reviewed; 1235 AA.
AC Q6ZQ73; Q6PHT7;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Cullin-associated NEDD8-dissociated protein 2;
DE AltName: Full=Cullin-associated and neddylation-dissociated protein 2;
DE AltName: Full=TBP-interacting protein of 120 kDa B;
DE Short=TBP-interacting protein 120B;
DE AltName: Full=p120 CAND2;
GN Name=Cand2; Synonyms=Kiaa0667, Tip120b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH CNOT3 AND TBP, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=12207886; DOI=10.1016/s0006-291x(02)02031-4;
RA Aoki T., Okada N., Wakamatsu T., Tamura T.-A.;
RT "TBP-interacting protein 120B, which is induced in relation to myogenesis,
RT binds to NOT3.";
RL Biochem. Biophys. Res. Commun. 296:1097-1103(2002).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Lung, Pancreas, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3
CC ubiquitin ligase complexes that promotes the exchange of the substrate-
CC recognition F-box subunit in SCF complexes, thereby playing a key role
CC in the cellular repertoire of SCF complexes. {ECO:0000250}.
CC -!- SUBUNIT: Binds TBP, CNOT3 and UBE3C. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6ZQ73; O75175: CNOT3; Xeno; NbExp=3; IntAct=EBI-6504831, EBI-743073;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in embryonic limb buds.
CC {ECO:0000269|PubMed:12207886}.
CC -!- PTM: Ubiquitinated and targeted for proteasomal degradation.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CAND family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC97996.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK129186; BAC97996.1; ALT_INIT; mRNA.
DR EMBL; BC056365; AAH56365.1; -; mRNA.
DR CCDS; CCDS20442.1; -.
DR RefSeq; NP_080234.2; NM_025958.2.
DR AlphaFoldDB; Q6ZQ73; -.
DR SMR; Q6ZQ73; -.
DR BioGRID; 211931; 11.
DR IntAct; Q6ZQ73; 3.
DR STRING; 10090.ENSMUSP00000075377; -.
DR iPTMnet; Q6ZQ73; -.
DR PhosphoSitePlus; Q6ZQ73; -.
DR EPD; Q6ZQ73; -.
DR MaxQB; Q6ZQ73; -.
DR PaxDb; Q6ZQ73; -.
DR PeptideAtlas; Q6ZQ73; -.
DR PRIDE; Q6ZQ73; -.
DR ProteomicsDB; 265527; -.
DR Antibodypedia; 5869; 68 antibodies from 21 providers.
DR DNASU; 67088; -.
DR Ensembl; ENSMUST00000075995; ENSMUSP00000075377; ENSMUSG00000030319.
DR GeneID; 67088; -.
DR KEGG; mmu:67088; -.
DR UCSC; uc009djb.2; mouse.
DR CTD; 23066; -.
DR MGI; MGI:1914338; Cand2.
DR VEuPathDB; HostDB:ENSMUSG00000030319; -.
DR eggNOG; KOG1824; Eukaryota.
DR GeneTree; ENSGT00390000017740; -.
DR HOGENOM; CLU_007157_0_0_1; -.
DR InParanoid; Q6ZQ73; -.
DR OMA; TNMRSDK; -.
DR OrthoDB; 194023at2759; -.
DR PhylomeDB; Q6ZQ73; -.
DR TreeFam; TF300355; -.
DR BioGRID-ORCS; 67088; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Cand2; mouse.
DR PRO; PR:Q6ZQ73; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q6ZQ73; protein.
DR Bgee; ENSMUSG00000030319; Expressed in interventricular septum and 168 other tissues.
DR Genevisible; Q6ZQ73; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0017025; F:TBP-class protein binding; IDA:MGI.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010265; P:SCF complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039852; CAND1/CAND2.
DR InterPro; IPR013932; TATA-bd_TIP120.
DR PANTHER; PTHR12696; PTHR12696; 1.
DR Pfam; PF08623; TIP120; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Acetylation; Nucleus; Reference proteome; Repeat; Ubl conjugation;
KW Ubl conjugation pathway.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O75155"
FT CHAIN 2..1235
FT /note="Cullin-associated NEDD8-dissociated protein 2"
FT /id="PRO_0000089298"
FT REPEAT 2..39
FT /note="HEAT 1"
FT REPEAT 44..81
FT /note="HEAT 2"
FT REPEAT 83..119
FT /note="HEAT 3"
FT REPEAT 129..167
FT /note="HEAT 4"
FT REPEAT 171..208
FT /note="HEAT 5"
FT REPEAT 210..246
FT /note="HEAT 6"
FT REPEAT 254..291
FT /note="HEAT 7"
FT REPEAT 326..367
FT /note="HEAT 8"
FT REPEAT 371..408
FT /note="HEAT 9"
FT REPEAT 431..468
FT /note="HEAT 10"
FT REPEAT 516..553
FT /note="HEAT 11"
FT REPEAT 564..603
FT /note="HEAT 12"
FT REPEAT 607..644
FT /note="HEAT 13"
FT REPEAT 647..684
FT /note="HEAT 14"
FT REPEAT 689..726
FT /note="HEAT 15"
FT REPEAT 730..769
FT /note="HEAT 16"
FT REPEAT 771..812
FT /note="HEAT 17"
FT REPEAT 856..893
FT /note="HEAT 18"
FT REPEAT 895..930
FT /note="HEAT 19"
FT REPEAT 932..965
FT /note="HEAT 20"
FT REPEAT 966..1002
FT /note="HEAT 21"
FT REPEAT 1006..1043
FT /note="HEAT 22"
FT REPEAT 1047..1083
FT /note="HEAT 23"
FT REPEAT 1104..1140
FT /note="HEAT 24"
FT REPEAT 1156..1193
FT /note="HEAT 25"
FT REPEAT 1203..1235
FT /note="HEAT 26"
FT REGION 314..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..343
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:O75155"
FT CONFLICT 1129
FT /note="I -> F (in Ref. 2; AAH56365)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1235 AA; 135633 MW; 534AC3D3633E0899 CRC64;
MSTGAFYISS LLEKMTSSDK DFRFMATSDL MSELQKDSIQ LDEDSERKVV RTLLRLLEDR
SGEVQNLAVK CLGPLVGKVK EYQVENIVDT LCANMRSDKE QLRDIAGIGL KTVLSELPPA
ATGSGLAINV CRKITGQLTS AIAQQEDVAV QLEALDILSD MLSRLGAPLG TFHASLLHCL
LPQLSSPRLA VRKRTVVALG HLAAACSTDL FVELADHLVD RLPGPRAPAS PAAIRTLIQC
LGSVGRQAGH RLGAHLDRLV PMVEEFCNLD DDELRESCLQ AFEAFLRKCP KEMDPHVPNV
TSLCLQYMKH DPNYDHDSDD EEQMETEDSE FSEQESEDEY SDDDDMSWKV RRAAAKCMAA
LISSRPDLLP DFHCTLAPAL IRRFKEREEN VKADIFGAYI MLLRHTRPPK GWLEAVEEPT
QTGRNLNMLR AQVPLVIKAL QRQLKDRNVR TRQGCFNLFT ELAGVLPGSL AEHMAVLVSG
IVFSLADYSS SSTIRMDALA FLQGLLGTEP AEAFHPHLPT LLPPVMACVA DPFYKVAAEA
LLVLQELVRT LWPLDRPRLL DPEPYVGEMS TATLARLRAT DLDQEVKERA ISCVGHLVGH
LGDRLGDDLE PTLMLLLDRL RNEITRLPAV KALTLVAMSP LRLDLQPILA EALPILASFL
RKNQRALRLA TLAALDALAQ SQGLGLPPPA VRTVLTELPA LVSENDMHVA QLAVDFLTTV
TQTQPSSLVE VSGPVLGELL QLLHSPLLPA GVLAATEGFL QALVGTRPPC VEYSELISLL
TAPVYNQVGD GGPGLHKQVF HSLARCVAAL SAACPQEAAG TASRLVCDAK SPHSSTGVKV
LAFLSLAEVG QVAGPGPQRE LKTVLLEALG SPSEDVRAAA AYALGRVGAG NLPDFLPFLL
AQIEAQPRRQ YLLLHALREA LGAAQPDNLK PYVEDVWALL FQRCESPEEG TRCVVAECIG
KLVFVNPPYL LPRFRKQLAA GQPYTRSTVI TAVKFLISDQ PHSIDPLLKS FIAEFMESLQ
DPDLNVRRAT LTFFNSAVHN KPSLVRDLLD DILPLLYQET KIRRDLIREV EMGPFKHTVD
DGLDVRKAAF ECMYSLLESC LGQLDMCEFL NHVEDGLKDH YDIRMLTFIM LARLATLCPA
PVLQRVDRLI EPLRATCTAK VKAGSVKQEL EKQEELKRSA MRAVAALLTN PEVRKSPTVA
DFSAQIRSNP ELTTLFESIQ KDTASGPSTD SMELS
