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XAPR_ECOLI
ID   XAPR_ECOLI              Reviewed;         294 AA.
AC   P23841; P76531;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=HTH-type transcriptional regulator XapR;
DE   AltName: Full=Xanthosine operon regulatory protein;
GN   Name=xapR; Synonyms=pndR, yfeB; OrderedLocusNames=b2405, JW2396;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2201776; DOI=10.1016/0022-2836(90)90339-n;
RA   Brun Y.V., Breton R., Lanouette P., Lapointe J.;
RT   "Precise mapping and comparison of two evolutionarily related regions of
RT   the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an
RT   ancestral tRNA operon.";
RL   J. Mol. Biol. 214:825-843(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA   Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA   Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA   Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT   genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT   its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31.
RC   STRAIN=K12;
RX   PubMed=7559336; DOI=10.1128/jb.177.19.5506-5516.1995;
RA   Seeger C., Poulsen C., Dandanell G.;
RT   "Identification and characterization of genes (xapA, xapB, and xapR)
RT   involved in xanthosine catabolism in Escherichia coli.";
RL   J. Bacteriol. 177:5506-5516(1995).
CC   -!- FUNCTION: Positive regulator required for the expression of xapA and
CC       xapB. Binds to the inducer xanthosine.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; X63976; CAA45390.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75458.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16273.1; -; Genomic_DNA.
DR   EMBL; M13687; AAA65714.1; -; Genomic_DNA.
DR   EMBL; X73828; CAA52047.1; -; Genomic_DNA.
DR   PIR; S11407; S11407.
DR   RefSeq; NP_416900.1; NC_000913.3.
DR   RefSeq; WP_000442949.1; NZ_LN832404.1.
DR   AlphaFoldDB; P23841; -.
DR   SMR; P23841; -.
DR   BioGRID; 4262007; 5.
DR   IntAct; P23841; 5.
DR   STRING; 511145.b2405; -.
DR   PaxDb; P23841; -.
DR   PRIDE; P23841; -.
DR   EnsemblBacteria; AAC75458; AAC75458; b2405.
DR   EnsemblBacteria; BAA16273; BAA16273; BAA16273.
DR   GeneID; 946862; -.
DR   KEGG; ecj:JW2396; -.
DR   KEGG; eco:b2405; -.
DR   PATRIC; fig|1411691.4.peg.4328; -.
DR   EchoBASE; EB1136; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_4_6; -.
DR   InParanoid; P23841; -.
DR   OMA; ERWICQP; -.
DR   PhylomeDB; P23841; -.
DR   BioCyc; EcoCyc:EG11146-MON; -.
DR   PRO; PR:P23841; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:EcoCyc.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd08449; PBP2_XapR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR037409; XapR_PBP2.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..294
FT                   /note="HTH-type transcriptional regulator XapR"
FT                   /id="PRO_0000105768"
FT   DOMAIN          7..64
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        24..43
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   294 AA;  33627 MW;  6DA7DA040C5D59A3 CRC64;
     MERVYRTDLK LLRYFLAVAE ELHFGRAAAR LNMSQPPLSI HIKELENQLG TQLFIRHSRS
     VVLTHAGKIL MEESRRLLVN ANNVLARIEQ IGRGEAGRIE LGVVGTAMWG RMRPVMRRFL
     RENPNVDVLF REKMPAMQMA LLERRELDAG IWRMATEPPT GFTSLRLHES AFLVAMPEEH
     HLSSFSTVPL EALRDEYFVT MPPVYTDWDF LQRVCQQVGF SPVVIREVNE PQTVLAMVSM
     GIGITLIADS YAQMNWPGVI FRPLKQRIPA DLYIVYETQQ VTPAMVKLLA ALTQ
 
 
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