CAND6_ARATH
ID CAND6_ARATH Reviewed; 428 AA.
AC Q9LZ39;
DT 31-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 6 {ECO:0000303|PubMed:18671868};
DE Short=AtCand6 {ECO:0000303|PubMed:18671868};
DE Flags: Precursor;
GN Name=CAND6 {ECO:0000303|PubMed:18671868};
GN OrderedLocusNames=At5g02630 {ECO:0000312|Araport:AT5G02630};
GN ORFNames=T22P11.220 {ECO:0000312|EMBL:CAB86000.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=17064408; DOI=10.1186/gb-2006-7-10-r96;
RA Moriyama E.N., Strope P.K., Opiyo S.O., Chen Z., Jones A.M.;
RT "Mining the Arabidopsis thaliana genome for highly-divergent seven
RT transmembrane receptors.";
RL Genome Biol. 7:R96.1-R96.9(2006).
RN [6]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18671868; DOI=10.1186/gb-2008-9-7-r120;
RA Gookin T.E., Kim J., Assmann S.M.;
RT "Whole proteome identification of plant candidate G-protein coupled
RT receptors in Arabidopsis, rice, and poplar: computational prediction and
RT in-vivo protein coupling.";
RL Genome Biol. 9:R120.1-R120.26(2008).
CC -!- FUNCTION: G-protein coupled receptor (PubMed:18671868). Plays a role in
CC plants and microbes interactions (By similarity).
CC {ECO:0000250|UniProtKB:Q94AH1, ECO:0000269|PubMed:18671868}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the LU7TM family. {ECO:0000305}.
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DR EMBL; AL162971; CAB86000.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90500.1; -; Genomic_DNA.
DR EMBL; BT005363; AAO63427.1; -; mRNA.
DR EMBL; AK117185; BAC41862.1; -; mRNA.
DR PIR; T48284; T48284.
DR RefSeq; NP_195883.1; NM_120341.3.
DR AlphaFoldDB; Q9LZ39; -.
DR STRING; 3702.AT5G02630.1; -.
DR PaxDb; Q9LZ39; -.
DR PRIDE; Q9LZ39; -.
DR ProteomicsDB; 187851; -.
DR EnsemblPlants; AT5G02630.1; AT5G02630.1; AT5G02630.
DR GeneID; 831851; -.
DR Gramene; AT5G02630.1; AT5G02630.1; AT5G02630.
DR KEGG; ath:AT5G02630; -.
DR Araport; AT5G02630; -.
DR TAIR; locus:2181783; AT5G02630.
DR eggNOG; KOG2569; Eukaryota.
DR HOGENOM; CLU_020277_4_0_1; -.
DR InParanoid; Q9LZ39; -.
DR OMA; ESNYIQR; -.
DR OrthoDB; 1427067at2759; -.
DR PhylomeDB; Q9LZ39; -.
DR PRO; PR:Q9LZ39; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LZ39; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR InterPro; IPR009637; GPR107/GPR108-like.
DR PANTHER; PTHR21229; PTHR21229; 1.
DR Pfam; PF06814; Lung_7-TM_R; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..428
FT /note="Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 6"
FT /id="PRO_5014313085"
FT TRANSMEM 173..193
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 428 AA; 48883 MW; 425E34860C0E1E18 CRC64;
MTILPFLAAV FVLQLLSTLT VAEIKSFTIS NDSRPVILLE KFGIIEIGHV TVSVSSVSVL
SPILDSSKLG FFVLSEESLP HVLLELQQNF SFCVLDSHYI LHFFTFVDLS PPPRSQFSKS
YPITSPNDYS LFFANCVPET RVSMKVHTEI YHDLYPNGSR DYLLAGSAQL PGLYLVFFLC
YLSFLCFWLC FCWNHKQIVK RIHLLMTALL LVKSLTLICA AVYKHYVKVT GTAHGWNIVF
YIFQFISVVL LFMVIVLIGN GWSFLKPKLH VKEKKLLVIV VPLQVLANIA SIVIGETGPY
TQDWVSWNQI FFLADITCCC AIVFAMVWSM CCLRETSKTD GKAVKNLAKL PVLRKFYVLV
IGYLFFTRIV VVVMKMKADF TYQWVSNAAE EIATLSFYCL MFYMFRPIEK NEYCDVDDEE
EIVELSLK
