XCL1_MOUSE
ID XCL1_MOUSE Reviewed; 114 AA.
AC P47993;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Lymphotactin;
DE AltName: Full=C motif chemokine 1;
DE AltName: Full=Cytokine SCM-1;
DE AltName: Full=Lymphotaxin;
DE AltName: Full=Small-inducible cytokine C1;
DE Flags: Precursor;
GN Name=Xcl1; Synonyms=Lptn, Ltn, Scyc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Thymus;
RX PubMed=7973732; DOI=10.1126/science.7973732;
RA Kelner G.S., Zlotnik A.;
RT "Lymphotactin: a cytokine that represents a new class of chemokine.";
RL Science 266:1395-1399(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Spleen;
RX PubMed=7875320; DOI=10.1016/0014-5793(95)00093-o;
RA Yoshida T., Imai T., Kakizaki M., Nishimura M., Yoshie O.;
RT "Molecular cloning of a novel C or gamma type chemokine, SCM-1.";
RL FEBS Lett. 360:155-159(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=9199871; DOI=10.1006/cyto.1996.0179;
RA Hautamaa D., Merica R., Chen Z., Jenkins M.K.;
RT "Murine lymphotactin: gene structure, post-translational modification and
RT inhibition of expression by CD28 costimulation.";
RL Cytokine 9:375-382(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=21300913; DOI=10.1084/jem.20102327;
RA Lei Y., Ripen A.M., Ishimaru N., Ohigashi I., Nagasawa T., Jeker L.T.,
RA Boesl M.R., Hollaender G.A., Hayashi Y., Malefyt R.W., Nitta T.,
RA Takahama Y.;
RT "Aire-dependent production of XCL1 mediates medullary accumulation of
RT thymic dendritic cells and contributes to regulatory T cell development.";
RL J. Exp. Med. 208:383-394(2011).
CC -!- FUNCTION: Chemotactic activity for lymphocytes but not for monocytes or
CC neutrophils. In thymus, mediates medullary accumulation of thymic
CC dendritic cells and contributes to regulatoy T cell development,
CC playing a role in self-tolerance establishment.
CC {ECO:0000269|PubMed:21300913}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in activated CD8(+) T cells. In the
CC thymus, expressed by medullary thymic epithelial cells.
CC {ECO:0000269|PubMed:21300913}.
CC -!- DISRUPTION PHENOTYPE: The thymus of knockout mice shows a lower
CC medullary accumulation of dendritic cells. Animals have a defective
CC generation of naturally ocurring regulatory T cells.
CC {ECO:0000269|PubMed:21300913}.
CC -!- SIMILARITY: Belongs to the intercrine gamma family. {ECO:0000305}.
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DR EMBL; U15607; AAA56752.1; -; mRNA.
DR EMBL; D43769; BAA07826.1; -; mRNA.
DR EMBL; U28493; AAA69801.1; -; Genomic_DNA.
DR EMBL; U28491; AAA69801.1; JOINED; Genomic_DNA.
DR EMBL; U28492; AAA69801.1; JOINED; Genomic_DNA.
DR EMBL; BC062249; AAH62249.1; -; mRNA.
DR CCDS; CCDS15438.1; -.
DR PIR; A55248; ETMSL.
DR RefSeq; NP_032536.1; NM_008510.1.
DR AlphaFoldDB; P47993; -.
DR SMR; P47993; -.
DR IntAct; P47993; 1.
DR STRING; 10090.ENSMUSP00000027860; -.
DR iPTMnet; P47993; -.
DR PhosphoSitePlus; P47993; -.
DR PaxDb; P47993; -.
DR PRIDE; P47993; -.
DR DNASU; 16963; -.
DR Ensembl; ENSMUST00000027860; ENSMUSP00000027860; ENSMUSG00000026573.
DR GeneID; 16963; -.
DR KEGG; mmu:16963; -.
DR UCSC; uc007dis.1; mouse.
DR CTD; 6375; -.
DR MGI; MGI:104593; Xcl1.
DR VEuPathDB; HostDB:ENSMUSG00000026573; -.
DR eggNOG; ENOG502S6ZP; Eukaryota.
DR GeneTree; ENSGT01050000244920; -.
DR HOGENOM; CLU_141716_2_0_1; -.
DR InParanoid; P47993; -.
DR OMA; QKWVQAA; -.
DR OrthoDB; 1553663at2759; -.
DR PhylomeDB; P47993; -.
DR TreeFam; TF334888; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 16963; 1 hit in 71 CRISPR screens.
DR PRO; PR:P47993; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P47993; protein.
DR Bgee; ENSMUSG00000026573; Expressed in thymus and 39 other tissues.
DR ExpressionAtlas; P47993; baseline and differential.
DR Genevisible; P47993; MM.
DR GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IDA:BHF-UCL.
DR GO; GO:0042379; F:chemokine receptor binding; IDA:BHF-UCL.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071353; P:cellular response to interleukin-4; IDA:BHF-UCL.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:BHF-UCL.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IDA:MGI.
DR GO; GO:0051649; P:establishment of localization in cell; IDA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0035782; P:mature natural killer cell chemotaxis; IDA:BHF-UCL.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:2000562; P:negative regulation of CD4-positive, alpha-beta T cell proliferation; ISS:BHF-UCL.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; ISS:BHF-UCL.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; ISS:BHF-UCL.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; ISS:BHF-UCL.
DR GO; GO:2000518; P:negative regulation of T-helper 1 cell activation; ISS:BHF-UCL.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:BHF-UCL.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:2000538; P:positive regulation of B cell chemotaxis; IDA:BHF-UCL.
DR GO; GO:2000563; P:positive regulation of CD4-positive, alpha-beta T cell proliferation; IDA:BHF-UCL.
DR GO; GO:2000566; P:positive regulation of CD8-positive, alpha-beta T cell proliferation; ISS:BHF-UCL.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:2000513; P:positive regulation of granzyme A production; ISS:BHF-UCL.
DR GO; GO:0071663; P:positive regulation of granzyme B production; ISS:BHF-UCL.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0002839; P:positive regulation of immune response to tumor cell; NAS:BHF-UCL.
DR GO; GO:2000558; P:positive regulation of immunoglobulin production in mucosal tissue; IDA:BHF-UCL.
DR GO; GO:0045089; P:positive regulation of innate immune response; IC:BHF-UCL.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; ISS:BHF-UCL.
DR GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; IDA:BHF-UCL.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; IDA:BHF-UCL.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IDA:BHF-UCL.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:BHF-UCL.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IDA:BHF-UCL.
DR GO; GO:0002726; P:positive regulation of T cell cytokine production; IDA:BHF-UCL.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISS:BHF-UCL.
DR GO; GO:2000556; P:positive regulation of T-helper 1 cell cytokine production; IDA:BHF-UCL.
DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IDA:BHF-UCL.
DR GO; GO:2000412; P:positive regulation of thymocyte migration; IDA:BHF-UCL.
DR GO; GO:0071636; P:positive regulation of transforming growth factor beta production; ISS:BHF-UCL.
DR GO; GO:0050727; P:regulation of inflammatory response; ISS:BHF-UCL.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:BHF-UCL.
DR CDD; cd00271; Chemokine_C; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR008105; Chemokine_XCL1/XCL2.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR PANTHER; PTHR12015:SF101; PTHR12015:SF101; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR01731; LYMPHOTACTIN.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..114
FT /note="Lymphotactin"
FT /id="PRO_0000005249"
FT REGION 92..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 32..69
FT /evidence="ECO:0000255"
FT CONFLICT 110
FT /note="I -> V (in Ref. 1; AAA56752)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 114 AA; 12467 MW; 04B51A5FCC61763B CRC64;
MRLLLLTFLG VCCLTPWVVE GVGTEVLEES SCVNLQTQRL PVQKIKTYII WEGAMRAVIF
VTKRGLKICA DPEAKWVKAA IKTVDGRAST RKNMAETVPT GAQRSTSTAI TLTG
