XCL1_RAT
ID XCL1_RAT Reviewed; 114 AA.
AC P51672;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Lymphotactin;
DE AltName: Full=C motif chemokine 1;
DE AltName: Full=Cytokine SCM-1;
DE AltName: Full=Small-inducible cytokine C1;
DE Flags: Precursor;
GN Name=Xcl1; Synonyms=Ltn, Scyc1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Long Evans; TISSUE=Lung;
RA Jones M.L.;
RL Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chemotactic activity for lymphocytes but not for monocytes or
CC neutrophils. In thymus, mediates medullary accumulation of thymic
CC dendritic cells and contributes to regulatoy T cell development,
CC playing a role in self-tolerance establishment.
CC {ECO:0000250|UniProtKB:P47993}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the intercrine gamma family. {ECO:0000305}.
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DR EMBL; U23377; AAA69478.1; -; mRNA.
DR RefSeq; NP_599188.1; NM_134361.1.
DR AlphaFoldDB; P51672; -.
DR SMR; P51672; -.
DR STRING; 10116.ENSRNOP00000003976; -.
DR PhosphoSitePlus; P51672; -.
DR PaxDb; P51672; -.
DR GeneID; 171371; -.
DR KEGG; rno:171371; -.
DR UCSC; RGD:620452; rat.
DR CTD; 6375; -.
DR RGD; 620452; Xcl1.
DR eggNOG; ENOG502S6ZP; Eukaryota.
DR InParanoid; P51672; -.
DR OrthoDB; 1553663at2759; -.
DR PhylomeDB; P51672; -.
DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:P51672; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; ISO:RGD.
DR GO; GO:0042379; F:chemokine receptor binding; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0007267; P:cell-cell signaling; ISO:RGD.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071353; P:cellular response to interleukin-4; ISO:RGD.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISO:RGD.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0035782; P:mature natural killer cell chemotaxis; ISO:RGD.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:2000562; P:negative regulation of CD4-positive, alpha-beta T cell proliferation; ISO:RGD.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; ISO:RGD.
DR GO; GO:0002725; P:negative regulation of T cell cytokine production; ISO:RGD.
DR GO; GO:2000518; P:negative regulation of T-helper 1 cell activation; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:2000538; P:positive regulation of B cell chemotaxis; ISO:RGD.
DR GO; GO:2000563; P:positive regulation of CD4-positive, alpha-beta T cell proliferation; ISO:RGD.
DR GO; GO:2000566; P:positive regulation of CD8-positive, alpha-beta T cell proliferation; ISO:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:2000513; P:positive regulation of granzyme A production; ISO:RGD.
DR GO; GO:0071663; P:positive regulation of granzyme B production; ISO:RGD.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:2000558; P:positive regulation of immunoglobulin production in mucosal tissue; ISO:RGD.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:RGD.
DR GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; ISO:RGD.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISO:RGD.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; ISO:RGD.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISO:RGD.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; ISO:RGD.
DR GO; GO:0002726; P:positive regulation of T cell cytokine production; ISO:RGD.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISO:RGD.
DR GO; GO:2000556; P:positive regulation of T-helper 1 cell cytokine production; ISO:RGD.
DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; ISO:RGD.
DR GO; GO:2000412; P:positive regulation of thymocyte migration; ISO:RGD.
DR GO; GO:0071636; P:positive regulation of transforming growth factor beta production; ISO:RGD.
DR GO; GO:0050727; P:regulation of inflammatory response; ISO:RGD.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISO:RGD.
DR GO; GO:0009615; P:response to virus; ISO:RGD.
DR CDD; cd00271; Chemokine_C; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR008105; Chemokine_XCL1/XCL2.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR PANTHER; PTHR12015:SF101; PTHR12015:SF101; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR01731; LYMPHOTACTIN.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
PE 3: Inferred from homology;
KW Chemotaxis; Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..114
FT /note="Lymphotactin"
FT /id="PRO_0000005250"
FT REGION 87..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 32..69
FT /evidence="ECO:0000255"
SQ SEQUENCE 114 AA; 12370 MW; 8E171C14F63172B0 CRC64;
MRLLLLTFLG VCCFAAWVVE GVGTEVLQES ICVSLRTQRL PVQKIKTYTI KEGAMRAVIF
VTKRGLRICA DPQAKWVKTA IKTVDGRASA SKSKAETIPT QAQRSASTAV TLTG
