XCL2_HUMAN
ID XCL2_HUMAN Reviewed; 114 AA.
AC Q9UBD3;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Cytokine SCM-1 beta;
DE AltName: Full=C motif chemokine 2;
DE AltName: Full=XC chemokine ligand 2;
DE Flags: Precursor;
GN Name=XCL2; Synonyms=SCYC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Placenta;
RX PubMed=8849694; DOI=10.1016/0014-5793(96)01004-6;
RA Yoshida T., Imai T., Takagi S., Nishimura M., Ishikawa I., Yaoi T.,
RA Yoshie O.;
RT "Structure and expression of two highly related genes encoding SCM-1/human
RT lymphotactin.";
RL FEBS Lett. 395:82-88(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 22-36.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: Chemotactic activity for lymphocytes but not for monocytes or
CC neutrophils. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9UBD3; P13501: CCL5; NbExp=2; IntAct=EBI-10319095, EBI-2848366;
CC Q9UBD3; P48061: CXCL12; NbExp=2; IntAct=EBI-10319095, EBI-3913254;
CC Q9UBD3; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10319095, EBI-11749135;
CC Q9UBD3; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10319095, EBI-10172052;
CC Q9UBD3; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10319095, EBI-945833;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the intercrine gamma family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=XCL2 entry;
CC URL="https://en.wikipedia.org/wiki/XCL2";
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DR EMBL; D63789; BAA09858.1; -; Genomic_DNA.
DR EMBL; AL031736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069360; AAH69360.1; -; mRNA.
DR EMBL; BC070308; AAH70308.1; -; mRNA.
DR CCDS; CCDS1273.1; -.
DR RefSeq; NP_003166.1; NM_003175.3.
DR AlphaFoldDB; Q9UBD3; -.
DR BMRB; Q9UBD3; -.
DR SMR; Q9UBD3; -.
DR BioGRID; 112713; 18.
DR IntAct; Q9UBD3; 17.
DR STRING; 9606.ENSP00000356793; -.
DR iPTMnet; Q9UBD3; -.
DR PhosphoSitePlus; Q9UBD3; -.
DR BioMuta; XCL2; -.
DR DMDM; 11387207; -.
DR MassIVE; Q9UBD3; -.
DR PaxDb; Q9UBD3; -.
DR PeptideAtlas; Q9UBD3; -.
DR PRIDE; Q9UBD3; -.
DR Antibodypedia; 72227; 21 antibodies from 12 providers.
DR DNASU; 6846; -.
DR Ensembl; ENST00000367819.3; ENSP00000356793.2; ENSG00000143185.4.
DR GeneID; 6846; -.
DR KEGG; hsa:6846; -.
DR MANE-Select; ENST00000367819.3; ENSP00000356793.2; NM_003175.4; NP_003166.1.
DR UCSC; uc001gfn.4; human.
DR CTD; 6846; -.
DR DisGeNET; 6846; -.
DR GeneCards; XCL2; -.
DR HGNC; HGNC:10646; XCL2.
DR HPA; ENSG00000143185; Tissue enhanced (bone marrow, lymphoid tissue).
DR MIM; 604828; gene.
DR neXtProt; NX_Q9UBD3; -.
DR OpenTargets; ENSG00000143185; -.
DR PharmGKB; PA35576; -.
DR VEuPathDB; HostDB:ENSG00000143185; -.
DR eggNOG; ENOG502S6ZP; Eukaryota.
DR GeneTree; ENSGT01050000244920; -.
DR HOGENOM; CLU_141716_2_0_1; -.
DR InParanoid; Q9UBD3; -.
DR OMA; QKWVQAA; -.
DR OrthoDB; 1553663at2759; -.
DR PhylomeDB; Q9UBD3; -.
DR TreeFam; TF334888; -.
DR PathwayCommons; Q9UBD3; -.
DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR SignaLink; Q9UBD3; -.
DR BioGRID-ORCS; 6846; 13 hits in 984 CRISPR screens.
DR GenomeRNAi; 6846; -.
DR Pharos; Q9UBD3; Tbio.
DR PRO; PR:Q9UBD3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9UBD3; protein.
DR Bgee; ENSG00000143185; Expressed in granulocyte and 91 other tissues.
DR Genevisible; Q9UBD3; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0008015; P:blood circulation; TAS:ProtInc.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR CDD; cd00271; Chemokine_C; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR008105; Chemokine_XCL1/XCL2.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; PTHR12015; 1.
DR PANTHER; PTHR12015:SF101; PTHR12015:SF101; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR01731; LYMPHOTACTIN.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; SSF54117; 1.
PE 1: Evidence at protein level;
KW Chemotaxis; Cytokine; Direct protein sequencing; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 22..114
FT /note="Cytokine SCM-1 beta"
FT /id="PRO_0000005251"
FT REGION 91..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 32..69
FT /evidence="ECO:0000255"
FT VARIANT 28
FT /note="H -> D (in dbSNP:rs4301615)"
FT /id="VAR_048713"
FT VARIANT 29
FT /note="R -> K (in dbSNP:rs4501820)"
FT /id="VAR_059212"
SQ SEQUENCE 114 AA; 12567 MW; E7F3C283F02D6D9D CRC64;
MRLLILALLG ICSLTAYIVE GVGSEVSHRR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF
ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG
