CAND7_ARATH
ID CAND7_ARATH Reviewed; 440 AA.
AC F4JY11; Q56YB8; Q681D1;
DT 31-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 7 {ECO:0000303|PubMed:18671868};
DE Short=AtCand7 {ECO:0000303|PubMed:18671868};
DE Flags: Precursor;
GN Name=CAND7 {ECO:0000303|PubMed:18671868};
GN OrderedLocusNames=At5g18520 {ECO:0000312|Araport:AT5G18520};
GN ORFNames=T28N17.5 {ECO:0000312|EMBL:AED92574.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY.
RX PubMed=17064408; DOI=10.1186/gb-2006-7-10-r96;
RA Moriyama E.N., Strope P.K., Opiyo S.O., Chen Z., Jones A.M.;
RT "Mining the Arabidopsis thaliana genome for highly-divergent seven
RT transmembrane receptors.";
RL Genome Biol. 7:R96.1-R96.9(2006).
RN [5]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18671868; DOI=10.1186/gb-2008-9-7-r120;
RA Gookin T.E., Kim J., Assmann S.M.;
RT "Whole proteome identification of plant candidate G-protein coupled
RT receptors in Arabidopsis, rice, and poplar: computational prediction and
RT in-vivo protein coupling.";
RL Genome Biol. 9:R120.1-R120.26(2008).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION BY N-ACYL-HOMOSERINE
RP LACTONES.
RC STRAIN=cv. Columbia;
RX PubMed=22206669; DOI=10.1016/j.bbrc.2011.12.066;
RA Jin G., Liu F., Ma H., Hao S., Zhao Q., Bian Z., Jia Z., Song S.;
RT "Two G-protein-coupled-receptor candidates, Cand2 and Cand7, are involved
RT in Arabidopsis root growth mediated by the bacterial quorum-sensing signals
RT N-acyl-homoserine lactones.";
RL Biochem. Biophys. Res. Commun. 417:991-995(2012).
CC -!- FUNCTION: Plays a role in plants and microbes interactions
CC (PubMed:22206669). G-protein coupled receptor involved in root growth
CC mediated by the bacterial quorum-sensing signals N-acyl-homoserine
CC lactones (AHLs) (PubMed:18671868, PubMed:22206669).
CC {ECO:0000269|PubMed:18671868, ECO:0000269|PubMed:22206669}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Induced by the N-acyl-homoserine lactones (AHLs) N-3-oxo-
CC hexanoyl-homoserine lactone (3OC6-HSL) and N-3-oxo-octanoyl-homoserine
CC lactone (3OC8-HSL). {ECO:0000269|PubMed:22206669}.
CC -!- DISRUPTION PHENOTYPE: Abolished Gram-negative bacteria-mediated
CC promotion of root elongation triggered by the N-acyl-homoserine
CC lactones (AHLs) N-3-oxo-hexanoyl-homoserine lactone (3OC6-HSL) and N-3-
CC oxo-octanoyl-homoserine lactone (3OC8-HSL).
CC {ECO:0000269|PubMed:22206669}.
CC -!- SIMILARITY: Belongs to the LU7TM family. {ECO:0000305}.
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DR EMBL; AC069328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92574.1; -; Genomic_DNA.
DR EMBL; AK175686; BAD43449.1; -; mRNA.
DR EMBL; AK221405; BAD94365.1; -; mRNA.
DR RefSeq; NP_197353.1; NM_121857.4.
DR AlphaFoldDB; F4JY11; -.
DR IntAct; F4JY11; 1.
DR STRING; 3702.AT5G18520.1; -.
DR PaxDb; F4JY11; -.
DR PRIDE; F4JY11; -.
DR ProteomicsDB; 201731; -.
DR EnsemblPlants; AT5G18520.1; AT5G18520.1; AT5G18520.
DR GeneID; 831970; -.
DR Gramene; AT5G18520.1; AT5G18520.1; AT5G18520.
DR KEGG; ath:AT5G18520; -.
DR Araport; AT5G18520; -.
DR TAIR; locus:2146233; AT5G18520.
DR eggNOG; KOG2569; Eukaryota.
DR HOGENOM; CLU_020277_4_0_1; -.
DR InParanoid; F4JY11; -.
DR OMA; IYLMIAF; -.
DR OrthoDB; 1427067at2759; -.
DR PRO; PR:F4JY11; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4JY11; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0002237; P:response to molecule of bacterial origin; IMP:UniProtKB.
DR GO; GO:0010015; P:root morphogenesis; IMP:TAIR.
DR InterPro; IPR009637; GPR107/GPR108-like.
DR PANTHER; PTHR21229; PTHR21229; 1.
DR Pfam; PF06814; Lung_7-TM_R; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..440
FT /note="Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 7"
FT /id="PRO_5003311573"
FT TRANSMEM 175..195
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 281
FT /note="V -> G (in Ref. 3; BAD43449)"
FT /evidence="ECO:0000305"
FT CONFLICT 346
FT /note="G -> D (in Ref. 3; BAD94365)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 440 AA; 50245 MW; 88FE6D603BA64E65 CRC64;
MAKMPLSVVV FLLFSAAFLA VSMAEIKSLV ISDDARPMIL FEKFGFTHTG HVTVSISSVS
VVSTSSDPNP EASRLGFFLL SEESLLQVLL EIQQNPRFCV LDSHYVTHLF TFRDLSPPPN
SRFNQSYPVT SPNEYSLFFA NCVPETKVSM AVRTEMYNKD PNGSKDYLPA GSTQLPTLYS
FFFLCYVAFL GFWSYTCWTN KQTVHRIHLL MAGLLLIKSL NLICAAEDKH YVKITGTPHG
WDILFYIFQF IRVVLLFTVI ILIGTGWSFL KPFLQEKEKN VLIIVIPLQV LANIASIVIG
ETGPFIKDWV TWNQVFLLVD IICCCAIIFP IVWSIRSLRE TSKTDGKAAR NLSKLTLFRQ
FYIVVIGYLY FTRIVVFALK TIAAYKYQWV SFAAEEIVSL VFYVIMFHMF RPEEKNEYFA
VDDDEEEAAA LALRDEEFEL
