XCR1_HUMAN
ID XCR1_HUMAN Reviewed; 333 AA.
AC P46094;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Chemokine XC receptor 1;
DE AltName: Full=G-protein coupled receptor 5;
DE AltName: Full=Lymphotactin receptor;
DE AltName: Full=XC chemokine receptor 1;
GN Name=XCR1; Synonyms=CCXCR1, GPR5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7832990; DOI=10.1089/dna.1995.14.25;
RA Heiber M., Docherty J.M., Shah G., Nguyen T., Cheng R., Heng H.H.Q.,
RA Marchese A., Tsui L.-C., Shi X., George S.R., O'Dowd B.F.;
RT "Isolation of three novel human genes encoding G protein-coupled
RT receptors.";
RL DNA Cell Biol. 14:25-35(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Warren C.N., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP CHARACTERIZATION.
RX PubMed=9632725; DOI=10.1074/jbc.273.26.16551;
RA Yoshida T., Imai T., Kakizaki M., Nishimura M., Takagi S., Yoshie O.;
RT "Identification of single C motif-1/lymphotactin receptor XCR1.";
RL J. Biol. Chem. 273:16551-16554(1998).
CC -!- FUNCTION: Receptor for chemokines SCYC1 and SCYC2. Subsequently
CC transduces a signal by increasing the intracellular calcium ions level.
CC Receptor for XCL1/Lymphotactin. {ECO:0000305}.
CC -!- INTERACTION:
CC P46094; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-12960721, EBI-742388;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; L36149; AAA62837.1; -; Genomic_DNA.
DR EMBL; AY275469; AAP32301.1; -; Genomic_DNA.
DR EMBL; BC069075; AAH69075.1; -; mRNA.
DR EMBL; BC069589; AAH69589.1; -; mRNA.
DR CCDS; CCDS2736.1; -.
DR PIR; I65989; I65989.
DR RefSeq; NP_001019815.1; NM_001024644.1.
DR RefSeq; NP_005274.1; NM_005283.2.
DR RefSeq; XP_016861685.1; XM_017006196.1.
DR RefSeq; XP_016861686.1; XM_017006197.1.
DR RefSeq; XP_016861687.1; XM_017006198.1.
DR RefSeq; XP_016861688.1; XM_017006199.1.
DR RefSeq; XP_016861689.1; XM_017006200.1.
DR RefSeq; XP_016861690.1; XM_017006201.1.
DR AlphaFoldDB; P46094; -.
DR SMR; P46094; -.
DR BioGRID; 109090; 2.
DR IntAct; P46094; 1.
DR STRING; 9606.ENSP00000310405; -.
DR ChEMBL; CHEMBL4339; -.
DR GuidetoPHARMACOLOGY; 75; -.
DR iPTMnet; P46094; -.
DR PhosphoSitePlus; P46094; -.
DR BioMuta; XCR1; -.
DR DMDM; 1170008; -.
DR PaxDb; P46094; -.
DR PeptideAtlas; P46094; -.
DR PRIDE; P46094; -.
DR Antibodypedia; 2956; 264 antibodies from 29 providers.
DR DNASU; 2829; -.
DR Ensembl; ENST00000309285.4; ENSP00000310405.3; ENSG00000173578.9.
DR Ensembl; ENST00000683768.1; ENSP00000507745.1; ENSG00000173578.9.
DR GeneID; 2829; -.
DR KEGG; hsa:2829; -.
DR MANE-Select; ENST00000309285.4; ENSP00000310405.3; NM_001024644.2; NP_001019815.1.
DR UCSC; uc003cpd.2; human.
DR CTD; 2829; -.
DR DisGeNET; 2829; -.
DR GeneCards; XCR1; -.
DR HGNC; HGNC:1625; XCR1.
DR HPA; ENSG00000173578; Tissue enhanced (lymphoid).
DR MIM; 600552; gene.
DR neXtProt; NX_P46094; -.
DR OpenTargets; ENSG00000173578; -.
DR PharmGKB; PA35037; -.
DR VEuPathDB; HostDB:ENSG00000173578; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244811; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; P46094; -.
DR OMA; RSHTKNR; -.
DR OrthoDB; 1285886at2759; -.
DR PhylomeDB; P46094; -.
DR TreeFam; TF330966; -.
DR PathwayCommons; P46094; -.
DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR SignaLink; P46094; -.
DR SIGNOR; P46094; -.
DR BioGRID-ORCS; 2829; 5 hits in 1063 CRISPR screens.
DR ChiTaRS; XCR1; human.
DR GeneWiki; XCR1; -.
DR GenomeRNAi; 2829; -.
DR Pharos; P46094; Tbio.
DR PRO; PR:P46094; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; P46094; protein.
DR Bgee; ENSG00000173578; Expressed in lymph node and 95 other tissues.
DR ExpressionAtlas; P46094; baseline and differential.
DR Genevisible; P46094; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0004950; F:chemokine receptor activity; TAS:ProtInc.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; TAS:ProtInc.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR InterPro; IPR005393; Chemokine_XCR1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01568; LYMPHOTACTNR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Chemokine XC receptor 1"
FT /id="PRO_0000070221"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 102..175
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 333 AA; 38508 MW; C84E7A3EF919CFA5 CRC64;
MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE
SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYSSIFFL
TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL
TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP
YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH
VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY
