XCR1_MOUSE
ID XCR1_MOUSE Reviewed; 322 AA.
AC Q9R0M1;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Chemokine XC receptor 1;
DE AltName: Full=Lymphotactin receptor;
DE AltName: Full=SCM1 receptor;
DE AltName: Full=XC chemokine receptor 1;
DE AltName: Full=mXCR1;
GN Name=Xcr1; Synonyms=Ccxcr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=10518929; DOI=10.1016/s0014-5793(99)01114-x;
RA Yoshida T., Izawa D., Nakayama T., Nakahara K., Kakizaki M., Imai T.,
RA Suzuki R., Miyasaka M., Yoshie O.;
RT "Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor.";
RL FEBS Lett. 458:37-40(1999).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=21300913; DOI=10.1084/jem.20102327;
RA Lei Y., Ripen A.M., Ishimaru N., Ohigashi I., Nagasawa T., Jeker L.T.,
RA Boesl M.R., Hollaender G.A., Hayashi Y., Malefyt R.W., Nitta T.,
RA Takahama Y.;
RT "Aire-dependent production of XCL1 mediates medullary accumulation of
RT thymic dendritic cells and contributes to regulatory T cell development.";
RL J. Exp. Med. 208:383-394(2011).
CC -!- FUNCTION: Receptor for chemokines SCYC1 and SCYC2. Subsequently
CC transduces a signal by increasing the intracellular calcium ions level.
CC Receptor for XCL1/Lymphotactin (Probable).
CC {ECO:0000305|PubMed:21300913}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed by dendritic cells from the thymus,
CC slpeen, subcutaneous lymph nodes and mesenteric lymph nodes.
CC {ECO:0000269|PubMed:21300913}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB028459; BAA85419.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9R0M1; -.
DR SMR; Q9R0M1; -.
DR STRING; 10090.ENSMUSP00000138255; -.
DR PhosphoSitePlus; Q9R0M1; -.
DR PaxDb; Q9R0M1; -.
DR PRIDE; Q9R0M1; -.
DR Antibodypedia; 2956; 264 antibodies from 29 providers.
DR Ensembl; ENSMUST00000182350; ENSMUSP00000138255; ENSMUSG00000060509.
DR MGI; MGI:1346338; Xcr1.
DR VEuPathDB; HostDB:ENSMUSG00000060509; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244811; -.
DR InParanoid; Q9R0M1; -.
DR OMA; RSHTKNR; -.
DR PhylomeDB; Q9R0M1; -.
DR TreeFam; TF330966; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR PRO; PR:Q9R0M1; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9R0M1; protein.
DR Bgee; ENSMUSG00000060509; Expressed in morula and 28 other tissues.
DR ExpressionAtlas; Q9R0M1; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IDA:MGI.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:MGI.
DR GO; GO:0034097; P:response to cytokine; IDA:MGI.
DR InterPro; IPR005393; Chemokine_XCR1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01568; LYMPHOTACTNR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..322
FT /note="Chemokine XC receptor 1"
FT /id="PRO_0000070222"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..243
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..283
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 97..170
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 322 AA; 37308 MW; 89A5573BD97A1CA3 CRC64;
MESSTAFYDY HDKLSLLCEN NVIFFSTIST IVLYSLVFLL SLVGNSLVLW VLVKYENLES
LTNIFILNLC LSDLMFSCLL PVLISAQWSW FLGDFFCKFF NMIFGISLYS SIFFLTIMTI
HRYLSVVSPI STLGIHTLRC RVLVTSCVWA ASILFSIPDA VFHKVISLNC KYSEHHGFLA
SVYQHNIFFL LSMGIILFCY VQILRTLFRT RSRQRHRTVR LIFTVVVAYF LSWAPYNLTL
FLKTGIIQQS CESLQQLDIA MIICRHLAFS HCCFNPVLYV FVGIKFRRHL KHLFQQVWLC
RKTSSTVPCS PGTFTYEGPS FY
