XCT_MOUSE
ID XCT_MOUSE Reviewed; 502 AA.
AC Q9WTR6;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Cystine/glutamate transporter;
DE AltName: Full=Amino acid transport system xc-;
DE AltName: Full=Solute carrier family 7 member 11;
DE AltName: Full=xCT;
GN Name=Slc7a11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10206947; DOI=10.1074/jbc.274.17.11455;
RA Sato H., Tamba M., Ishii T., Bannai S.;
RT "Cloning and expression of a plasma membrane cystine/glutamate exchange
RT transporter composed of two distinct proteins.";
RL J. Biol. Chem. 274:11455-11458(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/SvJ; TISSUE=Liver;
RX PubMed=12235164; DOI=10.1074/jbc.m208704200;
RA Sasaki H., Sato H., Kuriyama-Matsumura K., Sato K., Maebara K., Wang H.,
RA Tamba M., Itoh K., Yamamoto M., Bannai S.;
RT "Electrophile response element-mediated induction of the cystine/glutamate
RT exchange transporter gene expression.";
RL J. Biol. Chem. 277:44765-44771(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- FUNCTION: Sodium-independent, high-affinity exchange of anionic amino
CC acids with high specificity for anionic form of cystine and glutamate.
CC -!- SUBUNIT: Disulfide-linked heterodimer with the amino acid transport
CC protein SLC3A2/4F2hc.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000305}.
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DR EMBL; AB022345; BAA77220.1; -; mRNA.
DR EMBL; AB037661; BAA90522.1; -; Genomic_DNA.
DR CCDS; CCDS17335.1; -.
DR RefSeq; NP_036120.1; NM_011990.2.
DR AlphaFoldDB; Q9WTR6; -.
DR SMR; Q9WTR6; -.
DR STRING; 10090.ENSMUSP00000029297; -.
DR TCDB; 2.A.3.8.5; the amino acid-polyamine-organocation (apc) family.
DR iPTMnet; Q9WTR6; -.
DR PhosphoSitePlus; Q9WTR6; -.
DR MaxQB; Q9WTR6; -.
DR PaxDb; Q9WTR6; -.
DR PRIDE; Q9WTR6; -.
DR ProteomicsDB; 297652; -.
DR Antibodypedia; 16136; 341 antibodies from 37 providers.
DR DNASU; 26570; -.
DR Ensembl; ENSMUST00000029297; ENSMUSP00000029297; ENSMUSG00000027737.
DR GeneID; 26570; -.
DR KEGG; mmu:26570; -.
DR UCSC; uc008pdi.1; mouse.
DR CTD; 23657; -.
DR MGI; MGI:1347355; Slc7a11.
DR VEuPathDB; HostDB:ENSMUSG00000027737; -.
DR eggNOG; KOG1287; Eukaryota.
DR GeneTree; ENSGT00940000160324; -.
DR HOGENOM; CLU_007946_3_0_1; -.
DR InParanoid; Q9WTR6; -.
DR OMA; PHWVWVL; -.
DR OrthoDB; 621852at2759; -.
DR PhylomeDB; Q9WTR6; -.
DR TreeFam; TF313355; -.
DR Reactome; R-MMU-210991; Basigin interactions.
DR Reactome; R-MMU-352230; Amino acid transport across the plasma membrane.
DR BioGRID-ORCS; 26570; 11 hits in 77 CRISPR screens.
DR ChiTaRS; Slc7a11; mouse.
DR PRO; PR:Q9WTR6; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9WTR6; protein.
DR Bgee; ENSMUSG00000027737; Expressed in meninx of telencephalon and 111 other tissues.
DR ExpressionAtlas; Q9WTR6; baseline and differential.
DR Genevisible; Q9WTR6; MM.
DR GO; GO:0045177; C:apical part of cell; IDA:MGI.
DR GO; GO:0097449; C:astrocyte projection; IDA:MGI.
DR GO; GO:0031526; C:brush border membrane; IDA:MGI.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0005856; C:cytoskeleton; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0005791; C:rough endoplasmic reticulum; ISO:MGI.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030534; P:adult behavior; IDA:MGI.
DR GO; GO:0007420; P:brain development; IMP:MGI.
DR GO; GO:0034599; P:cellular response to oxidative stress; IMP:MGI.
DR GO; GO:0140206; P:dipeptide import across plasma membrane; IMP:MGI.
DR GO; GO:0090461; P:glutamate homeostasis; IMP:MGI.
DR GO; GO:0006749; P:glutathione metabolic process; IMP:MGI.
DR GO; GO:0034775; P:glutathione transmembrane transport; IDA:MGI.
DR GO; GO:0098712; P:L-glutamate import across plasma membrane; IMP:MGI.
DR GO; GO:0070306; P:lens fiber cell differentiation; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; IMP:MGI.
DR GO; GO:0048286; P:lung alveolus development; IMP:MGI.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IMP:MGI.
DR GO; GO:1903204; P:negative regulation of oxidative stress-induced neuron death; IDA:MGI.
DR GO; GO:0071702; P:organic substance transport; IMP:MGI.
DR GO; GO:0070527; P:platelet aggregation; IMP:MGI.
DR GO; GO:1904717; P:regulation of AMPA glutamate receptor clustering; IMP:MGI.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:MGI.
DR GO; GO:1900407; P:regulation of cellular response to oxidative stress; IMP:MGI.
DR GO; GO:1901494; P:regulation of cysteine metabolic process; IMP:MGI.
DR GO; GO:2000211; P:regulation of glutamate metabolic process; IMP:MGI.
DR GO; GO:1903786; P:regulation of glutathione biosynthetic process; IMP:MGI.
DR GO; GO:0048021; P:regulation of melanin biosynthetic process; IMP:MGI.
DR GO; GO:0033029; P:regulation of neutrophil apoptotic process; IMP:MGI.
DR GO; GO:0051223; P:regulation of protein transport; IMP:MGI.
DR GO; GO:0050807; P:regulation of synapse organization; IMP:MGI.
DR GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
DR GO; GO:0014070; P:response to organic cyclic compound; IMP:MGI.
DR GO; GO:0051775; P:response to redox state; IMP:MGI.
DR GO; GO:0009636; P:response to toxic substance; ISO:MGI.
DR GO; GO:0021756; P:striatum development; IMP:MGI.
DR GO; GO:0021591; P:ventricular system development; IMP:MGI.
DR GO; GO:0008542; P:visual learning; IMP:MGI.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004760; L_AA_transporter.
DR Pfam; PF13520; AA_permease_2; 1.
DR TIGRFAMs; TIGR00911; 2A0308; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Disulfide bond; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..502
FT /note="Cystine/glutamate transporter"
FT /id="PRO_0000054280"
FT TOPO_DOM 1..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..74
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..158
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..231
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..317
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..365
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 387
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 409..422
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 444..449
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 471..502
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 26
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
SQ SEQUENCE 502 AA; 55456 MW; A4A185102D83992A CRC64;
MVRKPVVATI SKGGYLQGNM SGRLPSMGDQ EPPGQEKVVL KKKITLLRGV SIIIGTVIGS
GIFISPKGIL QNTGSVGMSL VFWSACGVLS LFGALSYAEL GTSIKKSGGH YTYILEVFGP
LLAFVRVWVE LLVIRPGATA VISLAFGRYI LEPFFIQCEI PELAIKLVTA VGITVVMVLN
STSVSWSARI QIFLTFCKLT AILIIIVPGV IQLIKGQTHH FKDAFSGRDT SLMGLPLAFY
YGMYAYAGWF YLNFITEEVD NPEKTIPLAI CISMAIITVG YVLTNVAYFT TISAEELLQS
SAVAVTFSER LLGKFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV
HKHTPLPAVI VLHPLTMVML FSGDLYSLLN FLSFARWLFM GLAVAGLIYL RYKRPDMHRP
FKVPLFIPAL FSFTCLFMVV LSLYSDPFST GVGFLITLTG VPAYYLFIVW DKKPKWFRRL
SDRITRTLQI ILEVVPEDSK EL
