CAND8_ARATH
ID CAND8_ARATH Reviewed; 297 AA.
AC F4K2U8; O04651; Q8L8S4; Q94BV6;
DT 31-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 8 {ECO:0000303|PubMed:18671868};
DE Short=AtCand8 {ECO:0000303|PubMed:18671868};
GN Name=CAND8 {ECO:0000303|PubMed:18671868};
GN OrderedLocusNames=At5g27210 {ECO:0000312|Araport:AT5G27210};
GN ORFNames=T21B4.120 {ECO:0000312|EMBL:AAB61079.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=17064408; DOI=10.1186/gb-2006-7-10-r96;
RA Moriyama E.N., Strope P.K., Opiyo S.O., Chen Z., Jones A.M.;
RT "Mining the Arabidopsis thaliana genome for highly-divergent seven
RT transmembrane receptors.";
RL Genome Biol. 7:R96.1-R96.9(2006).
RN [6]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18671868; DOI=10.1186/gb-2008-9-7-r120;
RA Gookin T.E., Kim J., Assmann S.M.;
RT "Whole proteome identification of plant candidate G-protein coupled
RT receptors in Arabidopsis, rice, and poplar: computational prediction and
RT in-vivo protein coupling.";
RL Genome Biol. 9:R120.1-R120.26(2008).
CC -!- FUNCTION: G-protein coupled receptor (PubMed:18671868). Plays a role in
CC plants and microbes interactions (By similarity).
CC {ECO:0000250|UniProtKB:Q94AH1, ECO:0000269|PubMed:18671868}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the UPF0359 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB61079.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAK63964.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF007271; AAB61079.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED93658.1; -; Genomic_DNA.
DR EMBL; AY039860; AAK63964.1; ALT_FRAME; mRNA.
DR EMBL; AY088841; AAM67148.1; -; mRNA.
DR PIR; T01800; T01800.
DR RefSeq; NP_198073.1; NM_122603.2.
DR AlphaFoldDB; F4K2U8; -.
DR IntAct; F4K2U8; 38.
DR STRING; 3702.AT5G27210.1; -.
DR PaxDb; F4K2U8; -.
DR PRIDE; F4K2U8; -.
DR EnsemblPlants; AT5G27210.1; AT5G27210.1; AT5G27210.
DR GeneID; 832779; -.
DR Gramene; AT5G27210.1; AT5G27210.1; AT5G27210.
DR KEGG; ath:AT5G27210; -.
DR Araport; AT5G27210; -.
DR TAIR; locus:2181231; AT5G27210.
DR eggNOG; KOG4536; Eukaryota.
DR HOGENOM; CLU_078931_0_0_1; -.
DR InParanoid; F4K2U8; -.
DR OMA; NSRWREK; -.
DR OrthoDB; 948626at2759; -.
DR PRO; PR:F4K2U8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4K2U8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR InterPro; IPR018781; TPRA1/CAND2/CAND8.
DR PANTHER; PTHR15876; PTHR15876; 1.
DR Pfam; PF10160; Tmemb_40; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..297
FT /note="Protein CANDIDATE G-PROTEIN COUPLED RECEPTOR 8"
FT /id="PRO_0000447636"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 99
FT /note="G -> W (in Ref. 4; AAM67148)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 297 AA; 34138 MW; 9ED6AFA991F4B4B3 CRC64;
MRVLDEIAES PFLISPLNPN STANGYRWVD KCHGFLHNTV LVAASLFFVA YLAYEAKKSL
SKLSNRRSYI MIAYYGCLWL VSLLNLAWCC LQGWECTPGK EVVWNLLTLF TTSGMLFLEV
SLVAFLFQGN YASGAEALTR TFLISGFIVA LDLLLKAIFL FGFGVPLFID NNENGKTFKW
GLWIIHKLLL TGVYGMVFLM YNSRWREKLP ARPAFYNYII IMFALYSLYL VASAFTANNA
HFGFWLYGIM SVCYHALYLP LLYITFLADF FQEEDLNLEN VYYSEMKDAG FFDSDWE
