XDHC_ECOLI
ID XDHC_ECOLI Reviewed; 159 AA.
AC Q46801; Q2M9X2;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC;
GN Name=xdhC; Synonyms=ygeU; OrderedLocusNames=b2868, JW2836;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP DISCUSSION OF FUNCTION.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=10986234; DOI=10.1128/jb.182.19.5332-5341.2000;
RA Xi H., Schneider B.L., Reitzer L.;
RT "Purine catabolism in Escherichia coli and function of xanthine
RT dehydrogenase in purine salvage.";
RL J. Bacteriol. 182:5332-5341(2000).
CC -!- FUNCTION: Iron-sulfur subunit of the xanthine dehydrogenase complex.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250};
CC Note=Binds 2 [2Fe-2S] clusters. {ECO:0000250};
CC -!- PATHWAY: Purine metabolism; hypoxanthine degradation; urate from
CC hypoxanthine: step 1/2.
CC -!- SUBUNIT: Heterotrimer of XdhA, XdhB and XdhC. {ECO:0000305}.
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DR EMBL; U28375; AAA83049.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75906.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76934.1; -; Genomic_DNA.
DR PIR; D65070; D65070.
DR RefSeq; NP_417344.1; NC_000913.3.
DR RefSeq; WP_001016605.1; NZ_STEB01000001.1.
DR AlphaFoldDB; Q46801; -.
DR SMR; Q46801; -.
DR BioGRID; 4262321; 8.
DR BioGRID; 849536; 2.
DR ComplexPortal; CPX-5122; XdhABC xanthine dehydrogenase complex.
DR IntAct; Q46801; 4.
DR STRING; 511145.b2868; -.
DR PaxDb; Q46801; -.
DR PRIDE; Q46801; -.
DR EnsemblBacteria; AAC75906; AAC75906; b2868.
DR EnsemblBacteria; BAE76934; BAE76934; BAE76934.
DR GeneID; 945148; -.
DR KEGG; ecj:JW2836; -.
DR KEGG; eco:b2868; -.
DR PATRIC; fig|1411691.4.peg.3866; -.
DR EchoBASE; EB2863; -.
DR eggNOG; COG2080; Bacteria.
DR HOGENOM; CLU_052511_3_1_6; -.
DR InParanoid; Q46801; -.
DR OMA; QEADDVW; -.
DR PhylomeDB; Q46801; -.
DR BioCyc; EcoCyc:G7487-MON; -.
DR BioCyc; MetaCyc:G7487-MON; -.
DR UniPathway; UPA00604; UER00661.
DR PRO; PR:Q46801; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0002197; C:xanthine dehydrogenase complex; IC:ComplexPortal.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0009114; P:hypoxanthine catabolic process; IC:ComplexPortal.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IC:ComplexPortal.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR InterPro; IPR002888; 2Fe-2S-bd.
DR InterPro; IPR036884; 2Fe-2S-bd_dom_sf.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR Pfam; PF00111; Fer2; 1.
DR Pfam; PF01799; Fer2_2; 1.
DR SUPFAM; SSF47741; SSF47741; 1.
DR SUPFAM; SSF54292; SSF54292; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; Iron; Iron-sulfur; Metal-binding; Purine metabolism;
KW Purine salvage; Reference proteome.
FT CHAIN 1..159
FT /note="Putative xanthine dehydrogenase iron-sulfur-binding
FT subunit XdhC"
FT /id="PRO_0000189412"
FT DOMAIN 7..82
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT BINDING 44
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT BINDING 49
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
FT BINDING 52
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00465"
SQ SEQUENCE 159 AA; 16922 MW; B29F77F0DC06798C CRC64;
MNHSETITIE CTINGMPFQL HAAPGTPLSE LLREQGLLSV KQGCCVGECG ACTVLVDGTA
IDSCLYLAAW AEGKEIRTLE GEAKGGKLSH VQQAYAKSGA VQCGFCTPGL IMATTAMLAK
PREKPLTITE IRRGLAGNLC RCTGYQMIVN TVLDCEKTK
