ID   XEN1_XENLA              Reviewed;          84 AA.
AC   Q09022; Q9PRX9;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Xenoxin-1;
DE   Flags: Precursor;
GN   Name=xenoxin-1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 19-84.
RC   TISSUE=Skin, and Skin secretion;
RX   PubMed=8393864; DOI=10.1016/s0021-9258(19)85442-x;
RA   Kolbe H.V.J., Huber A., Cordier P., Rasmussen U.B., Bouchon B.,
RA   Jaquinod M., Vlasak R., Delot E.C., Kreil G.;
RT   "Xenoxins, a family of peptides from dorsal gland secretion of Xenopus
RT   laevis related to snake venom cytotoxins and neurotoxins.";
RL   J. Biol. Chem. 268:16458-16464(1993).
RN   [2]
RP   PROTEIN SEQUENCE OF 19-84, AND MASS SPECTROMETRY.
RC   TISSUE=Dorsal skin;
RX   PubMed=8203742; DOI=10.1006/abio.1994.1086;
RA   James S., Gibbs B.F., Toney K., Bennett H.P.J.;
RT   "Purification of antimicrobial peptides from an extract of the skin of
RT   Xenopus laevis using heparin-affinity HPLC: characterization by ion-spray
RT   mass spectrometry.";
RL   Anal. Biochem. 217:84-90(1994).
CC   -!- FUNCTION: Lacks alpha-neurotoxic activity, has apparently no
CC       antibacterial activity, nor anti-coagulant potency.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC   -!- MASS SPECTROMETRY: Mass=7227.9; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:8203742};
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DR   EMBL; X72673; CAA51225.1; -; mRNA.
DR   PIR; I51698; I51698.
DR   RefSeq; NP_001079296.1; NM_001085827.1.
DR   AlphaFoldDB; Q09022; -.
DR   SMR; Q09022; -.
DR   PRIDE; Q09022; -.
DR   GeneID; 378596; -.
DR   KEGG; xla:378596; -.
DR   CTD; 378596; -.
DR   Xenbase; XB-GENE-6252635; xenoxin1.L.
DR   OrthoDB; 1853023at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 378596; Expressed in zone of skin and 8 other tissues.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:8203742,
FT                   ECO:0000269|PubMed:8393864"
FT   CHAIN           19..84
FT                   /note="Xenoxin-1"
FT                   /id="PRO_0000010304"
FT   DISULFID        21..42
FT   DISULFID        35..55
FT   DISULFID        61..76
FT                   /evidence="ECO:0000250"
FT   DISULFID        77..82
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   84 AA;  9263 MW;  0CC8FADA3B2D776C CRC64;
     MRYAIVFFLV CVITLGEALK CVNLQANGIK MTQECAKEDT KCLTLRSLKK TLKFCASGRT
     CTTMKIMSLP GEQITCCEGN MCNA