ID   XEN2_XENLA              Reviewed;          66 AA.
AC   P38951;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Xenoxin-2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RX   PubMed=8393864; DOI=10.1016/s0021-9258(19)85442-x;
RA   Kolbe H.V.J., Huber A., Cordier P., Rasmussen U.B., Bouchon B.,
RA   Jaquinod M., Vlasak R., Delot E.C., Kreil G.;
RT   "Xenoxins, a family of peptides from dorsal gland secretion of Xenopus
RT   laevis related to snake venom cytotoxins and neurotoxins.";
RL   J. Biol. Chem. 268:16458-16464(1993).
CC   -!- FUNCTION: Lacks alpha-neurotoxic activity, has apparently no
CC       antibacterial activity, nor anti-coagulant potency.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
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DR   AlphaFoldDB; P38951; -.
DR   SMR; P38951; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing; Disulfide bond;
KW   Reference proteome; Secreted.
FT   CHAIN           1..66
FT                   /note="Xenoxin-2"
FT                   /id="PRO_0000190096"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250"
FT   DISULFID        17..37
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..64
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   66 AA;  7346 MW;  39AB6B2E77217B30 CRC64;
     LKCVNLQANG IKMTQECAKE DNKCLTLRSL KKTLKFCASD RICKTMKIMS LPGEKITCCE
     GNMCNA