ID   XENO_XENLA              Reviewed;          81 AA.
AC   P07198;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Xenopsin peptides;
DE   Contains:
DE     RecName: Full=Xenopsin precursor fragment;
DE              Short=XPF;
DE   Contains:
DE     RecName: Full=Xenopsin;
DE   Flags: Precursor;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=6582494; DOI=10.1073/pnas.81.2.380;
RA   Sures I., Crippa M.;
RT   "Xenopsin: the neurotensin-like octapeptide from Xenopus skin at the
RT   carboxyl terminus of its precursor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:380-384(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=2830279; DOI=10.1016/s0021-9258(18)69068-4;
RA   Poulter L., Terry A.S., Williams D.H., Giovannini M.G., Moore C.H.,
RA   Gibson B.W.;
RT   "Levitide, a neurohormone-like peptide from the skin of Xenopus laevis.
RT   Peptide and peptide precursor cDNA sequences.";
RL   J. Biol. Chem. 263:3279-3283(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2465151; DOI=10.1111/j.1432-1033.1989.tb14552.x;
RA   Kuchler K., Kreil G., Sures I.;
RT   "The genes for the frog skin peptides GLa, xenopsin, levitide and caerulein
RT   contain a homologous export exon encoding a signal sequence and part of an
RT   amphiphilic peptide.";
RL   Eur. J. Biochem. 179:281-285(1989).
RN   [4]
RP   PROTEIN SEQUENCE OF 39-63.
RC   TISSUE=Stomach;
RX   PubMed=1717472; DOI=10.1016/s0021-9258(18)55069-9;
RA   Moore K.S., Bevins C.L., Brasseur M.M., Tomassini N., Turner K., Eck H.,
RA   Zasloff M.;
RT   "Antimicrobial peptides in the stomach of Xenopus laevis.";
RL   J. Biol. Chem. 266:19851-19857(1991).
RN   [5]
RP   PROTEIN SEQUENCE OF 74-81.
RX   PubMed=4783175; DOI=10.1248/cpb.21.2801;
RA   Araki K., Tachibana S., Uchiyama M., Yasuhara T.;
RT   "Isolation and structure of a new active peptide 'Xenopsin' on the smooth
RT   muscle, especially on a strip of fundus from a rat stomach, from the skin
RT   of Xenopus laevis.";
RL   Chem. Pharm. Bull. 21:2801-2804(1973).
CC   -!- FUNCTION: Xenopsin is a neurotensin-like octapeptide.
CC   -!- FUNCTION: XPF has antimicrobial activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: XPF is synthesized in the stomach and stored in a
CC       novel granular multinucleated cell in the gastric mucosa, it is stored
CC       as active, processed peptides in large granules within the granular
CC       gland secretions of the skin.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family. Magainin
CC       subfamily. {ECO:0000305}.
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DR   EMBL; K02308; AAA49991.1; -; mRNA.
DR   EMBL; M18682; AAA49992.1; -; mRNA.
DR   EMBL; X13393; CAA31763.1; -; Genomic_DNA.
DR   EMBL; X13394; CAA31763.1; JOINED; Genomic_DNA.
DR   EMBL; X13395; CAA31763.1; JOINED; Genomic_DNA.
DR   PIR; A27785; A27785.
DR   RefSeq; NP_001079056.1; NM_001085587.1.
DR   AlphaFoldDB; P07198; -.
DR   TCDB; 1.C.16.1.3; the magainin (magainin) family.
DR   GeneID; 373587; -.
DR   KEGG; xla:373587; -.
DR   CTD; 373587; -.
DR   Xenbase; XB-GENE-6253058; levi.L.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 373587; Expressed in zone of skin and 10 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Reference proteome; Secreted; Signal;
KW   Vasoactive.
FT   SIGNAL          1..20
FT   PROPEP          21..37
FT                   /id="PRO_0000010706"
FT   PEPTIDE         39..63
FT                   /note="Xenopsin precursor fragment"
FT                   /id="PRO_0000010707"
FT   PROPEP          65..73
FT                   /note="Removed in mature form by a dipeptidylpeptidase"
FT                   /evidence="ECO:0000269|PubMed:4783175"
FT                   /id="PRO_0000010708"
FT   PEPTIDE         74..81
FT                   /note="Xenopsin"
FT                   /id="PRO_0000010709"
SQ   SEQUENCE   81 AA;  8962 MW;  13FBE9251C2F7B8D CRC64;
     MYKGIFLCVL LAVICANSLA TPSSDADEDN DEVERYVRGW ASKIGQTLGK IAKVGLKELI
     QPKREAMLRS AEAQGKRPWI L