ID   XERA_METTH              Reviewed;         311 AA.
AC   O26979;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Tyrosine recombinase XerA {ECO:0000255|HAMAP-Rule:MF_02055};
GN   Name=xerA {ECO:0000255|HAMAP-Rule:MF_02055}; OrderedLocusNames=MTH_893;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules.
CC       {ECO:0000255|HAMAP-Rule:MF_02055}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02055}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_02055}.
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DR   EMBL; AE000666; AAB85391.1; -; Genomic_DNA.
DR   PIR; D69219; D69219.
DR   RefSeq; WP_010876526.1; NC_000916.1.
DR   AlphaFoldDB; O26979; -.
DR   SMR; O26979; -.
DR   STRING; 187420.MTH_893; -.
DR   EnsemblBacteria; AAB85391; AAB85391; MTH_893.
DR   GeneID; 1471301; -.
DR   KEGG; mth:MTH_893; -.
DR   PATRIC; fig|187420.15.peg.878; -.
DR   HOGENOM; CLU_027562_9_6_2; -.
DR   OMA; HRFLYAE; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_02055; Recomb_XerA; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR033686; XerA.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding;
KW   Reference proteome.
FT   CHAIN           1..311
FT                   /note="Tyrosine recombinase XerA"
FT                   /id="PRO_0000095354"
FT   DOMAIN          21..107
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          122..306
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        169
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        193
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        258
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        261
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        284
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        293
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
SQ   SEQUENCE   311 AA;  36912 MW;  5E1746F4890A6B1F CRC64;
     MVDTMNMKRE SEERQGLLER YNFPELIEDY LIELEIRNYS PNTIKTYKSI VKNFYEFLMN
     EDDLYDDRRV LRSFKRYIQY LKRDKKVTQN YIYLVTVVVK KFFEFSGIDC LEEVKAPKRT
     KSLPKSLNED EVKSLINAVE VADDGSVIRR FIKTRDRLIL SLLYSSGLRV SELVSLRIND
     IDPDERTIRI RGKGDKDRIV LFDENTRDLL MDYLKRRIHE SEYLFLNRFG DPLTPRYVQM
     MIKNYARKAG IKKKVTPHIL RHSFATHLLK NGVDIRAIQQ LLGHSNLSTT QIYTSVDMQT
     LKNVYDRARL L