ID   XERA_PYRFU              Reviewed;         286 AA.
AC   Q8TZV9;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Tyrosine recombinase XerA {ECO:0000255|HAMAP-Rule:MF_02055};
GN   Name=xerA {ECO:0000255|HAMAP-Rule:MF_02055}; OrderedLocusNames=PF1868;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules.
CC       {ECO:0000255|HAMAP-Rule:MF_02055}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02055}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_02055}.
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DR   EMBL; AE009950; AAL81992.1; -; Genomic_DNA.
DR   RefSeq; WP_011013007.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8TZV9; -.
DR   SMR; Q8TZV9; -.
DR   STRING; 186497.PF1868; -.
DR   EnsemblBacteria; AAL81992; AAL81992; PF1868.
DR   GeneID; 41713688; -.
DR   KEGG; pfu:PF1868; -.
DR   PATRIC; fig|186497.12.peg.1938; -.
DR   eggNOG; arCOG01241; Archaea.
DR   HOGENOM; CLU_027562_9_5_2; -.
DR   OMA; HRFLYAE; -.
DR   OrthoDB; 57897at2157; -.
DR   PhylomeDB; Q8TZV9; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_02055; Recomb_XerA; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR033686; XerA.
DR   Pfam; PF13495; Phage_int_SAM_4; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding;
KW   Reference proteome.
FT   CHAIN           1..286
FT                   /note="Tyrosine recombinase XerA"
FT                   /id="PRO_0000095356"
FT   DOMAIN          5..82
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          98..274
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        135
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        160
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        226
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        229
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        252
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        261
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
SQ   SEQUENCE   286 AA;  33130 MW;  6E22174A80BE2B06 CRC64;
     MREKTLRSEV LEEFATYLEL EGKSKNTIRM YTYFLSKFLE EGYSPTARDA LRFLAKLRAK
     GYSIRSINLV VQALKAYFKF EGLNEEAERL RNPKIPKTLP KSLTEEEVKK LIEVIPKDKI
     RDRLIVLLLY GTGLRVSELC NLKIEDINFE KGFLTVRGGK GGKDRTIPIP QPLLTEIKNY
     LRRRTDDSPY LFVESRRKNK EKLSPKTVWR ILKEYGRKAG IKVTPHQLRH SFATHMLERG
     IDIRIIQELL GHASLSTTQI YTRVTAKHLK EAVERANLLE NLIGGE