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XERA_THEKO
ID   XERA_THEKO              Reviewed;         282 AA.
AC   Q5JHA3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Tyrosine recombinase XerA {ECO:0000255|HAMAP-Rule:MF_02055};
GN   Name=xerA {ECO:0000255|HAMAP-Rule:MF_02055}; OrderedLocusNames=TK0777;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules.
CC       {ECO:0000255|HAMAP-Rule:MF_02055}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02055}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_02055}.
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DR   EMBL; AP006878; BAD84966.1; -; Genomic_DNA.
DR   RefSeq; WP_011249728.1; NC_006624.1.
DR   AlphaFoldDB; Q5JHA3; -.
DR   SMR; Q5JHA3; -.
DR   STRING; 69014.TK0777; -.
DR   PRIDE; Q5JHA3; -.
DR   EnsemblBacteria; BAD84966; BAD84966; TK0777.
DR   GeneID; 3234254; -.
DR   KEGG; tko:TK0777; -.
DR   PATRIC; fig|69014.16.peg.757; -.
DR   eggNOG; arCOG01241; Archaea.
DR   HOGENOM; CLU_027562_9_5_2; -.
DR   InParanoid; Q5JHA3; -.
DR   OMA; TKVTVEH; -.
DR   OrthoDB; 57897at2157; -.
DR   PhylomeDB; Q5JHA3; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_02055; Recomb_XerA; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR033686; XerA.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding;
KW   Reference proteome.
FT   CHAIN           1..282
FT                   /note="Tyrosine recombinase XerA"
FT                   /id="PRO_0000095358"
FT   DOMAIN          2..79
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          95..271
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        132
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        157
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        223
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        226
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        249
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        258
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
SQ   SEQUENCE   282 AA;  32751 MW;  A4CCC0956E410E10 CRC64;
     MSEPNEVIEE FETYLDLEGK SPHTIRMYTY YVRRYLEWGG DLNAHSALRF LAHLRKNGYS
     NRSLNLVVQA LRAYFRFEGL DDEAERLKPP KVPRSLPKAL TREEVKRLLS VIPPTRKRDR
     LIVLLLYGAG LRVSELCNLK KDDVDLDRGL IVVRGGKGAK DRVVPIPKYL ADEIRAYLES
     RSDESEYLLV EDRRRRKDKL STRNVWYLLK RYGQKAGVEV TPHKLRHSFA THLLEEGVDI
     RAIQELLGHS NLSTTQIYTK VTVEHLRKAQ EKAKLIEKLM GE
 
 
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