ID   XERA_THEON              Reviewed;         282 AA.
AC   B6YWN8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Tyrosine recombinase XerA {ECO:0000255|HAMAP-Rule:MF_02055};
GN   Name=xerA {ECO:0000255|HAMAP-Rule:MF_02055}; OrderedLocusNames=TON_1013;
OS   Thermococcus onnurineus (strain NA1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=523850;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1;
RX   PubMed=18790866; DOI=10.1128/jb.00746-08;
RA   Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H.,
RA   Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J.,
RA   Colwell R.R., Kim S.-J., Lee J.-H.;
RT   "The complete genome sequence of Thermococcus onnurineus NA1 reveals a
RT   mixed heterotrophic and carboxydotrophic metabolism.";
RL   J. Bacteriol. 190:7491-7499(2008).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules.
CC       {ECO:0000255|HAMAP-Rule:MF_02055}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02055}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_02055}.
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DR   EMBL; CP000855; ACJ16501.1; -; Genomic_DNA.
DR   RefSeq; WP_012571973.1; NC_011529.1.
DR   AlphaFoldDB; B6YWN8; -.
DR   SMR; B6YWN8; -.
DR   STRING; 523850.TON_1013; -.
DR   EnsemblBacteria; ACJ16501; ACJ16501; TON_1013.
DR   GeneID; 7018032; -.
DR   KEGG; ton:TON_1013; -.
DR   PATRIC; fig|523850.10.peg.1021; -.
DR   eggNOG; arCOG01241; Archaea.
DR   HOGENOM; CLU_027562_9_5_2; -.
DR   OMA; TKVTVEH; -.
DR   OrthoDB; 57897at2157; -.
DR   Proteomes; UP000002727; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_02055; Recomb_XerA; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR033686; XerA.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding.
FT   CHAIN           1..282
FT                   /note="Tyrosine recombinase XerA"
FT                   /id="PRO_1000187616"
FT   DOMAIN          2..79
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          95..271
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        132
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        157
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        223
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        226
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        249
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
FT   ACT_SITE        258
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02055"
SQ   SEQUENCE   282 AA;  32689 MW;  46AE729ED90A9FD4 CRC64;
     MEAINEVIEE YETYLDLEGK SPNTIRMYSY YVRRYLEGGG ELKARSALRF LAKLRREGYS
     NKSLNLVVQA LRSYFRFEGY DEEAEKLRPP KVPKSLPKSL TREEVRKILS VIPPTKKRDR
     LIFLLLYGAG LRVSELCNLK KSDVDFERSL IIVRGGKGAK DRVVPIPAFL LEGIKAYLET
     RDDDSEYLIV EDRRERKDKL SPKTVWYLLK KYGDRAGIRV TPHMLRHSFA THMLENGVDI
     RAIQELLGHS NLSTTQIYTK VTVEHLRKAQ EKARLIEGLI EK