ID   XERC1_RALSO             Reviewed;         329 AA.
AC   Q8Y3C8;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Tyrosine recombinase XerC 1;
GN   Name=xerC1; OrderedLocusNames=RSc0052; ORFNames=RS01875;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules. The XerC-
CC       XerD complex is essential to convert dimers of the bacterial chromosome
CC       into monomers to permit their segregation at cell division. It also
CC       contributes to the segregational stability of plasmids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL646052; CAD13580.1; -; Genomic_DNA.
DR   RefSeq; WP_011000019.1; NC_003295.1.
DR   AlphaFoldDB; Q8Y3C8; -.
DR   SMR; Q8Y3C8; -.
DR   STRING; 267608.RSc0052; -.
DR   EnsemblBacteria; CAD13580; CAD13580; RSc0052.
DR   GeneID; 60499561; -.
DR   KEGG; rso:RSc0052; -.
DR   eggNOG; COG4973; Bacteria.
DR   HOGENOM; CLU_027562_9_0_4; -.
DR   OMA; HSFASHM; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR011931; Recomb_XerC.
DR   InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   TIGRFAMs; TIGR02224; recomb_XerC; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   DNA integration; DNA recombination; DNA-binding; Reference proteome.
FT   CHAIN           1..329
FT                   /note="Tyrosine recombinase XerC 1"
FT                   /id="PRO_0000095318"
FT   DOMAIN          14..101
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          123..320
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        163
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        198
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        272
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        275
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        298
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        307
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   329 AA;  36008 MW;  1A344F941D27E177 CRC64;
     MPPSAPDDDR DAPAPPHPQI GAYLDALKFE RKLSQHTLAS YARELAVLQQ LGARFAAGID
     LMRLQPHHIR RMMAQLHGGG LSGRSIARAL SAWRGWYQWL ALRDAAVTAN PVDGIRAPKS
     PKRLPKALSV EQAVALMEQL PGDDPEAVRD RAVNELFYSC GLRLSELVGL DLRHAQAGDY
     ASASWLDLEA REVTVLGKGN KRRTVPVGSK AAEALAAWLA VRPQLAQPDA APEDAHALFL
     SARGKRLAQR QIQTRMKRNA IAAGVPADVH PHVLRHSFAT HMLQSSGDLR AVQELLGHAS
     IASTQVYTSL DFQHLAKIYD QAHPRAKKK