XERC_BRUSU
ID XERC_BRUSU Reviewed; 315 AA.
AC Q7ZAN7; G0K859;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2003, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Tyrosine recombinase XerC {ECO:0000255|HAMAP-Rule:MF_01808};
GN Name=xerC {ECO:0000255|HAMAP-Rule:MF_01808};
GN OrderedLocusNames=BR1916, BS1330_I1910;
OS Brucella suis biovar 1 (strain 1330).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=204722;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=12271122; DOI=10.1073/pnas.192319099;
RA Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT "The Brucella suis genome reveals fundamental similarities between animal
RT and plant pathogens and symbionts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=22038969; DOI=10.1128/jb.06181-11;
RA Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT "Revised genome sequence of Brucella suis 1330.";
RL J. Bacteriol. 193:6410-6410(2011).
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules. The XerC-
CC XerD complex is essential to convert dimers of the bacterial chromosome
CC into monomers to permit their segregation at cell division. It also
CC contributes to the segregational stability of plasmids.
CC {ECO:0000255|HAMAP-Rule:MF_01808}.
CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC molecules of XerC and two molecules of XerD. {ECO:0000255|HAMAP-
CC Rule:MF_01808}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01808}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01808}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014291; AAN30808.1; -; Genomic_DNA.
DR EMBL; CP002997; AEM19225.1; -; Genomic_DNA.
DR RefSeq; WP_002964984.1; NZ_KN046804.1.
DR AlphaFoldDB; Q7ZAN7; -.
DR SMR; Q7ZAN7; -.
DR PRIDE; Q7ZAN7; -.
DR EnsemblBacteria; AEM19225; AEM19225; BS1330_I1910.
DR GeneID; 45052866; -.
DR GeneID; 55591507; -.
DR KEGG; bms:BR1916; -.
DR KEGG; bsi:BS1330_I1910; -.
DR PATRIC; fig|204722.21.peg.2556; -.
DR HOGENOM; CLU_027562_9_0_5; -.
DR OMA; HSFASHM; -.
DR PhylomeDB; Q7ZAN7; -.
DR Proteomes; UP000007104; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; -; 1.
DR HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; SSF56349; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW DNA integration; DNA recombination; DNA-binding.
FT CHAIN 1..315
FT /note="Tyrosine recombinase XerC"
FT /id="PRO_0000095287"
FT DOMAIN 13..104
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT DOMAIN 125..309
FT /note="Tyr recombinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 168
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01808"
FT ACT_SITE 193
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01808"
FT ACT_SITE 261
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01808"
FT ACT_SITE 264
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01808"
FT ACT_SITE 287
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01808"
FT ACT_SITE 296
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01808"
SQ SEQUENCE 315 AA; 34050 MW; C3CB7B18420174F1 CRC64;
MATNSEFLIP ARADLAAARE EWLKSLKTMR RLSDNTLIAY ERDTRQFLQF LTGHLGEPPS
LKEIGNLRIA DLRSFLANRR NDGAGARTLG RGLAGVRSLL RHLEKRGLVN AAGASAMRAP
RQPKSLPKPL TADDARRVVS ADGQMAEEPW IAARNAAVLT LLYGCGLRIS EALGLSGDAL
SDPSARSMTI TGKGSKTRLV PLLPAVHKAV AQYRALCPFD LSAGQPLFRG AKGGPLHAAI
IQREMQKLRA GLGLPDSATP HALRHSFATH LLGRGGDLRT IQELLGHASL STTQVYTGVD
TQRLLEVYDK THPRA
