ID   CAO1A_XENLA             Reviewed;         560 AA.
AC   Q9DEX1; Q32N99; Q5PPT0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Calcium-binding and coiled-coil domain-containing protein 1-A;
DE   AltName: Full=Nuclear domain 10 protein NDP52;
DE   AltName: Full=Protein Xdsg;
GN   Name=calcoco1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=14747946; DOI=10.1007/s00427-004-0382-8;
RA   Yamakita S., Mishima Y., Ikenishi K.;
RT   "A novel gene, the protein product of which is mainly expressed in germline
RT   cells and in the dorsal structures of Xenopus.";
RL   Dev. Genes Evol. 214:89-95(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a coactivator for aryl hydrocarbon and
CC       nuclear receptors. {ECO:0000250|UniProtKB:Q8CGU1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14747946}. Nucleus
CC       {ECO:0000269|PubMed:14747946}. Note=Detected in the cytoplasm at stages
CC       I- II. Detected in the nucleus and the cytoplasm, except for the germ
CC       plasm, of almost all cells in cleaving embryos,.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9DEX1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9DEX1-2; Sequence=VSP_029055;
CC   -!- DEVELOPMENTAL STAGE: Expressed in the germinal vesicle of oocytes at
CC       stages I-III. Expressed in ectodermal and mesodermal cells and their
CC       derivatives after stage 10. At stages later than 28, highly expressed
CC       in the myotome, spinal cord and notochord (at protein level).
CC       {ECO:0000269|PubMed:14747946}.
CC   -!- SIMILARITY: Belongs to the CALCOCO family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH87514.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF312719; AAG33628.1; -; mRNA.
DR   EMBL; BC087514; AAH87514.1; ALT_INIT; mRNA.
DR   EMBL; BC108760; AAI08761.1; -; mRNA.
DR   RefSeq; NP_001082045.1; NM_001088576.2.
DR   AlphaFoldDB; Q9DEX1; -.
DR   SMR; Q9DEX1; -.
DR   DNASU; 398195; -.
DR   GeneID; 398195; -.
DR   KEGG; xla:398195; -.
DR   CTD; 398195; -.
DR   Xenbase; XB-GENE-6251912; calcoco1.S.
DR   OrthoDB; 179838at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 398195; Expressed in heart and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012852; CALCOCO1-like.
DR   InterPro; IPR041611; SKICH.
DR   Pfam; PF07888; CALCOCO1; 2.
DR   Pfam; PF17751; SKICH; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..560
FT                   /note="Calcium-binding and coiled-coil domain-containing
FT                   protein 1-A"
FT                   /id="PRO_0000308904"
FT   REGION          480..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          156..192
FT                   /evidence="ECO:0000255"
FT   COILED          367..480
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..13
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_029055"
FT   CONFLICT        112
FT                   /note="R -> H (in Ref. 1; AAG33628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        126
FT                   /note="A -> S (in Ref. 1; AAG33628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        224
FT                   /note="I -> K (in Ref. 1; AAG33628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        258
FT                   /note="N -> D (in Ref. 2; AAH87514)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        407
FT                   /note="H -> Q (in Ref. 1; AAG33628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        441
FT                   /note="T -> A (in Ref. 1; AAG33628)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   560 AA;  64384 MW;  B0FCEDC0B73FFBBF CRC64;
     MELILYVCKK VNIMENISQP QLPMGVSFLN VAHTYVPNTK VECHYTIPFG MKSSTRDWIG
     IFKVNTSSIR DYETFVWAVP PENAGERSIS HCSVQFQAYY LPHPGEQQYH FRYVDQCGSV
     RGCSEAFVFG EPQPMEEMVT LEDEDSCLDM LLIVPKATFL QNQLEMAQKE RNDLMRARLA
     LEEEVISKEK RICYLEAALD ISEKTCFSLK EQCEDLVTRE QIAIGERNLL NCQEAELRER
     ILQLESEIQS MNKKMQENDR VLEGTVAIKF SLETEKGELK QRLGETTVEI ERYQLQVDSL
     REKLRSSQDM LSSSQQKALL MGEELASMSS IRDCTISDLH KSRLETADLA IKVSDLSVKF
     KEGMGQWWQE KTALNHSMEA KRDQIVNLKA EKLSLDNSLQ EERSQRHALQ CKLNQETDAR
     QVQLSENRRE LSELKSALKV TQMEKEQLIE ERQEIHQYVR RLEERLDKLA DEKWKEDKML
     MEDKTDSSPP TLSVDLSDSD DESPGDEGVS QQLGPCSLDE QDLSLNLPVF PCEPQKVVIN
     QPAPIACQLQ PLPEDNPDSW