ID   XERDL_LACLA             Reviewed;         238 AA.
AC   Q9CG32;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Tyrosine recombinase XerD-like;
GN   Name=ynbA; OrderedLocusNames=LL1278; ORFNames=L109747;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
RN   [2]
RP   LACK OF FUNCTION IN DNA RECOMBINATION.
RX   PubMed=17630835; DOI=10.1371/journal.pgen.0030117;
RA   Le Bourgeois P., Bugarel M., Campo N., Daveran-Mingot M.-L., Labonte J.,
RA   Lanfranchi D., Lautier T., Pages C., Ritzenthaler P.;
RT   "The unconventional Xer recombination machinery of
RT   Streptococci/Lactococci.";
RL   PLoS Genet. 3:E117-E117(2007).
CC   -!- FUNCTION: Putative tyrosine recombinase. Not involved in the cutting
CC       and rejoining of the recombining DNA molecules on dif(SL) site.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD-like
CC       subfamily. {ECO:0000305}.
CC   -!- CAUTION: Although strongly related to XerD, it constitutes a distinct
CC       protein family. In contrast to the classic XerD protein, it does not
CC       contain the Arg-His-Arg-His (R-H-R-H) sandwich residues that are
CC       clustered with the Tyr active site. It also lacks the C-terminal region
CC       which is known to mediate the interaction with XerC. It is therefore
CC       unknown whether it has tyrosine recombinase activity or acts as a
CC       regulator. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK05376.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005176; AAK05376.1; ALT_INIT; Genomic_DNA.
DR   PIR; F86784; F86784.
DR   RefSeq; NP_267434.2; NC_002662.1.
DR   RefSeq; WP_010905864.1; NC_002662.1.
DR   AlphaFoldDB; Q9CG32; -.
DR   SMR; Q9CG32; -.
DR   STRING; 272623.L109747; -.
DR   PaxDb; Q9CG32; -.
DR   DNASU; 1114927; -.
DR   EnsemblBacteria; AAK05376; AAK05376; L109747.
DR   GeneID; 66442234; -.
DR   KEGG; lla:L109747; -.
DR   PATRIC; fig|272623.7.peg.1381; -.
DR   eggNOG; COG4974; Bacteria.
DR   HOGENOM; CLU_1128554_0_0_9; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01817; Recomb_XerD_like; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR020876; Tyrosine_recombinase_XerD-like.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA recombination; DNA-binding; Reference proteome.
FT   CHAIN           1..238
FT                   /note="Tyrosine recombinase XerD-like"
FT                   /id="PRO_0000355189"
FT   DOMAIN          1..75
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          90..238
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        154
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        204
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        236
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   238 AA;  28212 MW;  112E1488ADEAB63B CRC64;
     MKLPNEIDEY LASRNFSENT RSNYHYDLVS LQAFFEDKSL TTENLELYKI QISNLSPAAQ
     RRKISSANQY LLFLYQRQKV DQYFKIKQVV QKKSQTAQSY HPMIKEFPEF YGPLTCPGQF
     LALLILEFGL NFAEIQKLKW ENFNWNFKYL TIEKAGIKRV LPIREKFAIR VKAINNADEL
     FAKSRQFLYT ELKKFTNYSS KEIREQYILH QVKAGKSIYE LATLLGLTTI TTLEKYYR