ID   XERDL_STRMT             Reviewed;         244 AA.
AC   Q9EUR3;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2003, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Tyrosine recombinase XerD-like {ECO:0000255|HAMAP-Rule:MF_01817};
GN   Name=xerD;
OS   Streptococcus mitis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=28037;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=476;
RX   PubMed=11763967;
RA   Reichmann P., Hakenbeck R.;
RT   "A XerD recombinase with unusual active site motifs in Streptococcus
RT   pneumoniae.";
RL   J. Mol. Microbiol. Biotechnol. 4:101-110(2002).
CC   -!- FUNCTION: Putative tyrosine recombinase. Not involved in the cutting
CC       and rejoining of the recombining DNA molecules on dif(SL) site.
CC       {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD-like
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- CAUTION: Although named XerD by PubMed:11763967, it is not the ortholog
CC       of XerD and constitutes a distinct protein family. In contrast to the
CC       classic XerD protein, it does not contain the Arg-His-Arg-His (R-H-R-H)
CC       sandwich residues that are clustered with the Tyr active site. It also
CC       lacks the C-terminal region which is known to mediate the interaction
CC       with XerC. It is therefore unknown whether it has tyrosine recombinase
CC       activity or act as a regulator. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC19443.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ277490; CAC19443.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q9EUR3; -.
DR   SMR; Q9EUR3; -.
DR   STRING; 585202.SMSK321_1125; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01817; Recomb_XerD_like; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR020876; Tyrosine_recombinase_XerD-like.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding.
FT   CHAIN           1..244
FT                   /note="Tyrosine recombinase XerD-like"
FT                   /id="PRO_0000095438"
FT   DOMAIN          1..73
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          90..244
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        150
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        211
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        243
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   244 AA;  28152 MW;  1EAF659769C54AF6 CRC64;
     MRDRISDFLE EKHGLSANSK QSYKYDLEQC LDIVGERISD TSLKIYQAQL ANLKISAQKR
     KISGCNQFLY FLYHKGEMDS FDRLESAKQA EKKAEKPEIL DLDSFWQGSD FPEGRLLALL
     ILEMGLLPSE ILALKVADIN LDFQVLRIQK ASQQRIVTIP TSLLSELEPL MGQTYLFERT
     GKAYSRQWAF RQLEAFVKEK GFPALSAQAL REQFILRQIE NKVDLYEIAK KSGLKTVLTL
     EKYR