ID   XERDL_STRMU             Reviewed;         245 AA.
AC   Q8DSQ9;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Tyrosine recombinase XerD-like {ECO:0000255|HAMAP-Rule:MF_01817};
GN   OrderedLocusNames=SMU_1714c;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Putative tyrosine recombinase. Not involved in the cutting
CC       and rejoining of the recombining DNA molecules on dif(SL) site.
CC       {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD-like
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01817}.
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DR   EMBL; AE014133; AAN59349.1; -; Genomic_DNA.
DR   RefSeq; NP_722043.1; NC_004350.2.
DR   RefSeq; WP_002262560.1; NC_004350.2.
DR   AlphaFoldDB; Q8DSQ9; -.
DR   SMR; Q8DSQ9; -.
DR   STRING; 210007.SMU_1714c; -.
DR   PRIDE; Q8DSQ9; -.
DR   EnsemblBacteria; AAN59349; AAN59349; SMU_1714c.
DR   KEGG; smu:SMU_1714c; -.
DR   PATRIC; fig|210007.7.peg.1532; -.
DR   eggNOG; COG0582; Bacteria.
DR   HOGENOM; CLU_1128554_0_0_9; -.
DR   OMA; QVGQRIN; -.
DR   PhylomeDB; Q8DSQ9; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01817; Recomb_XerD_like; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR020876; Tyrosine_recombinase_XerD-like.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding;
KW   Reference proteome.
FT   CHAIN           1..245
FT                   /note="Tyrosine recombinase XerD-like"
FT                   /id="PRO_0000095439"
FT   DOMAIN          1..72
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          90..245
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        151
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        210
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        242
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   245 AA;  28515 MW;  E49808A6C3119B18 CRC64;
     MITFISKFLA SKSLTLNSQK SYLYDLQQFA EIIGEEVTPN KLKLYEQSLA DLKVSAKKRK
     ISAVNQFLFF LYENEVLDRF YKIKNKEKLP LLTPAYQEVD LSVLYRKIGD SKGQLIALLI
     VELGLSPSEI IQLKWENIAL EFQVLTIVNE KVMRILEIPQ LLLPYLEGEH KAVYLFDNKG
     EAYSRQWLFQ KLNYYLASVD LSQMTAQKLR EQYIIKEKNK GTAILDLTRK LGLKSPVTLE
     KYFKN