ID   XERDL_STRP3             Reviewed;         248 AA.
AC   P0DH46; Q8K8I6;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Tyrosine recombinase XerD-like {ECO:0000255|HAMAP-Rule:MF_01817};
GN   OrderedLocusNames=SpyM3_0266;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- FUNCTION: Putative tyrosine recombinase. Not involved in the cutting
CC       and rejoining of the recombining DNA molecules on dif(SL) site.
CC       {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD-like
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01817}.
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DR   EMBL; AE014074; AAM78873.1; -; Genomic_DNA.
DR   RefSeq; WP_011054211.1; NC_004070.1.
DR   AlphaFoldDB; P0DH46; -.
DR   SMR; P0DH46; -.
DR   EnsemblBacteria; AAM78873; AAM78873; SpyM3_0266.
DR   GeneID; 57852135; -.
DR   KEGG; spg:SpyM3_0266; -.
DR   HOGENOM; CLU_1128554_0_0_9; -.
DR   OMA; QVGQRIN; -.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01817; Recomb_XerD_like; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR020876; Tyrosine_recombinase_XerD-like.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding.
FT   CHAIN           1..248
FT                   /note="Tyrosine recombinase XerD-like"
FT                   /id="PRO_0000095443"
FT   DOMAIN          1..72
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          85..248
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        149
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        213
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        245
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   248 AA;  28804 MW;  1B1BA161095C69A3 CRC64;
     MKSYIEPFIA SKALSQNSQK AYRYDLQQFC QLVGERVNQD KLLLYQNSIA NLSLSAKKRK
     LSTANQFLYY LYQIKYLNSY FRLTDTMKVM RTEKQQAAII NTDIFYQKTP FVWGQLISLL
     ILELGLTPSE VAGIEVANLD LSFQMLTLKT KKGVRVLPLS QILIPFLEQQ LIGKEVYLFE
     HRGIPFSRQW FFNHLKTFVR SIGYEGLTAQ KLREQFILKE KLAGKSIIEL SDILGLKSPV
     TLEKYYKS