ID   XERDL_STRPI             Reviewed;         244 AA.
AC   B1I887;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Tyrosine recombinase XerD-like {ECO:0000255|HAMAP-Rule:MF_01817};
GN   OrderedLocusNames=SPH_1993;
OS   Streptococcus pneumoniae (strain Hungary19A-6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=487214;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hungary19A-6;
RX   PubMed=21034474; DOI=10.1186/gb-2010-11-10-r107;
RA   Donati C., Hiller N.L., Tettelin H., Muzzi A., Croucher N.J.,
RA   Angiuoli S.V., Oggioni M., Dunning Hotopp J.C., Hu F.Z., Riley D.R.,
RA   Covacci A., Mitchell T.J., Bentley S.D., Kilian M., Ehrlich G.D.,
RA   Rappuoli R., Moxon E.R., Masignani V.;
RT   "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and
RT   closely related species.";
RL   Genome Biol. 11:R107.1-R107.19(2010).
CC   -!- FUNCTION: Putative tyrosine recombinase. Not involved in the cutting
CC       and rejoining of the recombining DNA molecules on dif(SL) site.
CC       {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD-like
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACA35610.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000936; ACA35610.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; B1I887; -.
DR   SMR; B1I887; -.
DR   EnsemblBacteria; ACA35610; ACA35610; SPH_1993.
DR   KEGG; spv:SPH_1993; -.
DR   HOGENOM; CLU_1128554_0_0_9; -.
DR   Proteomes; UP000002163; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01817; Recomb_XerD_like; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR020876; Tyrosine_recombinase_XerD-like.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding.
FT   CHAIN           1..244
FT                   /note="Tyrosine recombinase XerD-like"
FT                   /id="PRO_0000355192"
FT   DOMAIN          1..73
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          90..244
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        150
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        211
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        243
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   244 AA;  28429 MW;  2FAA8FF1844D02A8 CRC64;
     MRDRISAFLE EKQGLSVNSK QSYKYDLEQF LDMVGERISE TSLKIYQAQL ANLKISAQKR
     KISACNQFLY FLYQKGEVDS FYRLELAKQA EKKTEKPEIL YLDSFWQESD HPEGRLLALL
     ILEMGLLPSE ILAIKVADIN LDFQVLRISK ASQRRIVTIP TALLSELEPL MGQTYLFERG
     GKPYSRQWAF RQLESFVKEK GFPSLSAQVL REQFILRQIE NKVDLYEIAK KLGLKTVLTL
     EKYR