ID   XERDL_STRPN             Reviewed;         244 AA.
AC   P0A4S9; Q9EUQ8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Tyrosine recombinase XerD-like {ECO:0000255|HAMAP-Rule:MF_01817};
GN   OrderedLocusNames=SP_1877;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Putative tyrosine recombinase. Not involved in the cutting
CC       and rejoining of the recombining DNA molecules on dif(SL) site.
CC       {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- INTERACTION:
CC       P0A4S9; Q97NV3: groES; NbExp=2; IntAct=EBI-2207382, EBI-2206949;
CC       P0A4S9; Q97QV8: rex; NbExp=2; IntAct=EBI-2207382, EBI-2207177;
CC       P0A4S9; P67049: thyA; NbExp=2; IntAct=EBI-2207382, EBI-2207093;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD-like
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK75949.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005672; AAK75949.1; ALT_INIT; Genomic_DNA.
DR   PIR; D95219; D95219.
DR   AlphaFoldDB; P0A4S9; -.
DR   SMR; P0A4S9; -.
DR   IntAct; P0A4S9; 3.
DR   STRING; 170187.SP_1877; -.
DR   EnsemblBacteria; AAK75949; AAK75949; SP_1877.
DR   KEGG; spn:SP_1877; -.
DR   eggNOG; COG4974; Bacteria.
DR   OMA; QVGQRIN; -.
DR   PhylomeDB; P0A4S9; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01817; Recomb_XerD_like; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR020876; Tyrosine_recombinase_XerD-like.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding.
FT   CHAIN           1..244
FT                   /note="Tyrosine recombinase XerD-like"
FT                   /id="PRO_0000095440"
FT   DOMAIN          1..73
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          90..244
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        150
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        211
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        243
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   244 AA;  28473 MW;  031A8FA1E77D31A9 CRC64;
     MRDRISAFLE EKQGLSVNSK QSYKYDLEQF LDMVGERISE TSLKIYQAQL ANLKISAQKR
     KISACNQFLY FLYQKGEVDS FYRLELAKQA EKKTEKPEIL YLDSFWQESD HPEGRLLALL
     ILEMGLLPSE ILAIKVADIN LDFQVLRISK ASQQRIVTIP TALLSELEPL MGQTYLFERG
     EKPYSRQWAF RQLESFVKEK GFPSLSAQVL REQFILRQIE NKVDLYEIAK KLGLKTVLTL
     EKYR