ID   XERDL_STRR6             Reviewed;         244 AA.
AC   P0A4T0; Q9EUQ8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Tyrosine recombinase XerD-like {ECO:0000255|HAMAP-Rule:MF_01817};
GN   Name=xerD; OrderedLocusNames=spr1692;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RX   PubMed=11763967;
RA   Reichmann P., Hakenbeck R.;
RT   "A XerD recombinase with unusual active site motifs in Streptococcus
RT   pneumoniae.";
RL   J. Mol. Microbiol. Biotechnol. 4:101-110(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- FUNCTION: Putative tyrosine recombinase. Not involved in the cutting
CC       and rejoining of the recombining DNA molecules on dif(SL) site.
CC       {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- DISRUPTION PHENOTYPE: Cells display severe growth defects.
CC       {ECO:0000269|PubMed:11763967}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD-like
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- CAUTION: Although named XerD by PubMed:11763967, it is not the ortholog
CC       of XerD and constitutes a distinct protein family. In contrast to the
CC       classic XerD protein, it does not contain the Arg-His-Arg-His (R-H-R-H)
CC       sandwich residues that are clustered with the Tyr active site. It also
CC       lacks the C-terminal region which is known to mediate the interaction
CC       with XerC. It is therefore unknown whether it has tyrosine recombinase
CC       activity or act as a regulator. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL00495.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAC19448.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ277766; CAC19448.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE007317; AAL00495.1; ALT_INIT; Genomic_DNA.
DR   PIR; B98083; B98083.
DR   RefSeq; NP_359284.1; NC_003098.1.
DR   RefSeq; WP_001132186.1; NC_003098.1.
DR   AlphaFoldDB; P0A4T0; -.
DR   SMR; P0A4T0; -.
DR   STRING; 171101.spr1692; -.
DR   EnsemblBacteria; AAL00495; AAL00495; spr1692.
DR   GeneID; 60233905; -.
DR   KEGG; spr:spr1692; -.
DR   PATRIC; fig|171101.6.peg.1830; -.
DR   eggNOG; COG4974; Bacteria.
DR   HOGENOM; CLU_1128554_0_0_9; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01817; Recomb_XerD_like; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR020876; Tyrosine_recombinase_XerD-like.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding;
KW   Reference proteome.
FT   CHAIN           1..244
FT                   /note="Tyrosine recombinase XerD-like"
FT                   /id="PRO_0000095441"
FT   DOMAIN          1..73
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          90..244
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        150
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        211
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        243
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   244 AA;  28473 MW;  031A8FA1E77D31A9 CRC64;
     MRDRISAFLE EKQGLSVNSK QSYKYDLEQF LDMVGERISE TSLKIYQAQL ANLKISAQKR
     KISACNQFLY FLYQKGEVDS FYRLELAKQA EKKTEKPEIL YLDSFWQESD HPEGRLLALL
     ILEMGLLPSE ILAIKVADIN LDFQVLRISK ASQQRIVTIP TALLSELEPL MGQTYLFERG
     EKPYSRQWAF RQLESFVKEK GFPSLSAQVL REQFILRQIE NKVDLYEIAK KLGLKTVLTL
     EKYR