ID   XERDL_STRT2             Reviewed;         253 AA.
AC   Q5M623;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Tyrosine recombinase XerD-like {ECO:0000255|HAMAP-Rule:MF_01817};
GN   OrderedLocusNames=stu0259;
OS   Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=264199;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-250 / LMG 18311;
RX   PubMed=15543133; DOI=10.1038/nbt1034;
RA   Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA   Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M.,
RA   Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D.,
RA   Hancy F., Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.;
RT   "Complete sequence and comparative genome analysis of the dairy bacterium
RT   Streptococcus thermophilus.";
RL   Nat. Biotechnol. 22:1554-1558(2004).
CC   -!- FUNCTION: Putative tyrosine recombinase. Not involved in the cutting
CC       and rejoining of the recombining DNA molecules on dif(SL) site.
CC       {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01817}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD-like
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01817}.
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DR   EMBL; CP000023; AAV59983.1; -; Genomic_DNA.
DR   RefSeq; WP_011225439.1; NC_006448.1.
DR   AlphaFoldDB; Q5M623; -.
DR   SMR; Q5M623; -.
DR   STRING; 264199.stu0259; -.
DR   EnsemblBacteria; AAV59983; AAV59983; stu0259.
DR   GeneID; 66898189; -.
DR   KEGG; stl:stu0259; -.
DR   eggNOG; COG4974; Bacteria.
DR   HOGENOM; CLU_1128554_0_0_9; -.
DR   OMA; QVGQRIN; -.
DR   Proteomes; UP000001170; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01817; Recomb_XerD_like; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR020876; Tyrosine_recombinase_XerD-like.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding;
KW   Reference proteome.
FT   CHAIN           1..253
FT                   /note="Tyrosine recombinase XerD-like"
FT                   /id="PRO_0000355197"
FT   DOMAIN          8..81
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          93..253
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        157
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        218
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        250
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   253 AA;  28741 MW;  D2C6125C4336FA93 CRC64;
     MTISSFQKQL TTQITNFLAR KTISDSSKQA YAYDLKQFVN CLPGRVDQTS LKLYENQLKE
     WKPSVQKRKR SAVNQFLLYL YQKGELEEFF KLSETAPLPS QQEELEIFDL SSLYEGQEGP
     GKLACLFILE LGLLPSEILE LKWEDIDLDF GVVTVAKGST KRVLRLDGAL KELLFGIKND
     NSQGLILSKA FTRQWLYKQI QSYVGGCGLS GVTAQALRQQ YILRQIEKGT GAFELARLLG
     LKSPVTLEKY YKT