XERD_PSEAE
ID XERD_PSEAE Reviewed; 298 AA.
AC Q9HXQ6;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Tyrosine recombinase XerD {ECO:0000255|HAMAP-Rule:MF_01807};
GN Name=xerD {ECO:0000255|HAMAP-Rule:MF_01807}; OrderedLocusNames=PA3738;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules. The XerC-
CC XerD complex is essential to convert dimers of the bacterial chromosome
CC into monomers to permit their segregation at cell division. It also
CC contributes to the segregational stability of plasmids.
CC {ECO:0000255|HAMAP-Rule:MF_01807}.
CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC molecules of XerC and two molecules of XerD. {ECO:0000255|HAMAP-
CC Rule:MF_01807}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01807}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01807}.
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DR EMBL; AE004091; AAG07125.1; -; Genomic_DNA.
DR PIR; F83177; F83177.
DR RefSeq; NP_252427.1; NC_002516.2.
DR RefSeq; WP_003092629.1; NZ_QZGE01000001.1.
DR AlphaFoldDB; Q9HXQ6; -.
DR SMR; Q9HXQ6; -.
DR STRING; 287.DR97_4138; -.
DR PaxDb; Q9HXQ6; -.
DR DNASU; 880331; -.
DR EnsemblBacteria; AAG07125; AAG07125; PA3738.
DR GeneID; 880331; -.
DR KEGG; pae:PA3738; -.
DR PATRIC; fig|208964.12.peg.3910; -.
DR PseudoCAP; PA3738; -.
DR HOGENOM; CLU_027562_9_0_6; -.
DR InParanoid; Q9HXQ6; -.
DR OMA; QAFWYLI; -.
DR PhylomeDB; Q9HXQ6; -.
DR BioCyc; PAER208964:G1FZ6-3809-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; -; 1.
DR HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR HAMAP; MF_01807; Recomb_XerD; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR011932; Recomb_XerD.
DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; SSF56349; 1.
DR TIGRFAMs; TIGR02225; recomb_XerD; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW DNA integration; DNA recombination; DNA-binding; Reference proteome.
FT CHAIN 1..298
FT /note="Tyrosine recombinase XerD"
FT /id="PRO_0000095405"
FT DOMAIN 3..88
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT DOMAIN 109..292
FT /note="Tyr recombinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 149
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01807"
FT ACT_SITE 173
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01807"
FT ACT_SITE 244
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01807"
FT ACT_SITE 247
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01807"
FT ACT_SITE 270
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01807"
FT ACT_SITE 279
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01807"
SQ SEQUENCE 298 AA; 33628 MW; CAA7FCB8364886E5 CRC64;
MSTLEHPLID RFLDALWLEK GLADNTREAY RNDLQQFNAW LDGRGLRLEG IGRDAILDHL
AWRLEQGYKA RSTARFLSGL RGFYRYCLRD GLIAEDPTLQ VDLPQLGKPL PKSLSEADVE
ALLAAPEVDD PLGLRDRTML EVLYACGLRV SELVGLTLEQ VNLRQGVVKV FGKGSKERLV
PLGEEAIGWL ERYLREARGD LLGGRPSDVL FPSLRGEQMT RQTFWHRIKH HAQVAAIGTS
ISPHTLRHAF ATHLLNHGAD LRVVQMLLGH SDLSTTQIYT HIARARLQDL HARHHPRG
