ID   XERS_STRGC              Reviewed;         356 AA.
AC   A8AXA5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Tyrosine recombinase XerS {ECO:0000255|HAMAP-Rule:MF_01816};
GN   Name=xerS {ECO:0000255|HAMAP-Rule:MF_01816}; OrderedLocusNames=SGO_1126;
OS   Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 /
OS   DL1 / V288).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=467705;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288;
RX   PubMed=17720781; DOI=10.1128/jb.01023-07;
RA   Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.;
RT   "Genome-wide transcriptional changes in Streptococcus gordonii in response
RT   to competence signaling peptide.";
RL   J. Bacteriol. 189:7799-7807(2007).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules. Essential
CC       to convert dimers of the bacterial chromosome into monomers to permit
CC       their segregation at cell division. {ECO:0000255|HAMAP-Rule:MF_01816}.
CC   -!- ACTIVITY REGULATION: FtsK is required for recombination.
CC       {ECO:0000255|HAMAP-Rule:MF_01816}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01816}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerS subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01816}.
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DR   EMBL; CP000725; ABV11074.1; -; Genomic_DNA.
DR   RefSeq; WP_012000536.1; NC_009785.1.
DR   AlphaFoldDB; A8AXA5; -.
DR   SMR; A8AXA5; -.
DR   STRING; 467705.SGO_1126; -.
DR   EnsemblBacteria; ABV11074; ABV11074; SGO_1126.
DR   KEGG; sgo:SGO_1126; -.
DR   eggNOG; COG4974; Bacteria.
DR   HOGENOM; CLU_027562_9_6_9; -.
DR   OMA; EKNGAHM; -.
DR   Proteomes; UP000001131; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01816; Recomb_XerS; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR023670; Recomb_XerS.
DR   Pfam; PF13495; Phage_int_SAM_4; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   DNA integration; DNA recombination; DNA-binding; Reference proteome.
FT   CHAIN           1..356
FT                   /note="Tyrosine recombinase XerS"
FT                   /id="PRO_1000088328"
FT   DOMAIN          16..121
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          169..354
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        210
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT   ACT_SITE        234
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT   ACT_SITE        306
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT   ACT_SITE        309
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT   ACT_SITE        332
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT   ACT_SITE        341
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
SQ   SEQUENCE   356 AA;  41352 MW;  EB4D017057289A2F CRC64;
     MRRELLLERI DKLKATMPWY ILEYYQSKLA VPYSFTTLYE YLKEYDRFFN WVLESGITNA
     SHIAEIPLSV LENMTKKDME AFILYLRERP LLNANTTQNG VSQTTINRTL SALSSLYKYL
     TEEVENEQGE PYFYRNVMKK VATKKKKETL AARAENIKQK LFLGDETEEF LQYIDREYPK
     KLSNRALSSF NKNKERDLAI IALLLASGVR LSEAVNLDLK DINLKMMVIE VTRKGGKRDS
     VNVAAFAKPY LEEYLSIRSK RYKAEKTDTA FFLTEYRGTP NRIDASSVEK MVAKYSEDFK
     VRVTPHKLRH TLATRLYDAT KSQVLVSHQL GHASTQVTDL YTHIVNDEQK NALNKL