XERS_STRSV
ID XERS_STRSV Reviewed; 356 AA.
AC A3CN22;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Tyrosine recombinase XerS {ECO:0000255|HAMAP-Rule:MF_01816};
GN Name=xerS {ECO:0000255|HAMAP-Rule:MF_01816}; OrderedLocusNames=SSA_1171;
OS Streptococcus sanguinis (strain SK36).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=388919;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK36;
RX PubMed=17277061; DOI=10.1128/jb.01808-06;
RA Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL J. Bacteriol. 189:3166-3175(2007).
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules. Essential
CC to convert dimers of the bacterial chromosome into monomers to permit
CC their segregation at cell division. {ECO:0000255|HAMAP-Rule:MF_01816}.
CC -!- ACTIVITY REGULATION: FtsK is required for recombination.
CC {ECO:0000255|HAMAP-Rule:MF_01816}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01816}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerS subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01816}.
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DR EMBL; CP000387; ABN44577.1; -; Genomic_DNA.
DR RefSeq; WP_011836963.1; NC_009009.1.
DR RefSeq; YP_001035127.1; NC_009009.1.
DR AlphaFoldDB; A3CN22; -.
DR SMR; A3CN22; -.
DR STRING; 388919.SSA_1171; -.
DR EnsemblBacteria; ABN44577; ABN44577; SSA_1171.
DR KEGG; ssa:SSA_1171; -.
DR PATRIC; fig|388919.9.peg.1114; -.
DR eggNOG; COG4974; Bacteria.
DR HOGENOM; CLU_027562_9_6_9; -.
DR OMA; EKNGAHM; -.
DR OrthoDB; 745068at2; -.
DR Proteomes; UP000002148; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; -; 1.
DR HAMAP; MF_01816; Recomb_XerS; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR023670; Recomb_XerS.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; SSF56349; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW DNA integration; DNA recombination; DNA-binding; Reference proteome.
FT CHAIN 1..356
FT /note="Tyrosine recombinase XerS"
FT /id="PRO_1000070250"
FT DOMAIN 16..121
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT DOMAIN 169..354
FT /note="Tyr recombinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT ACT_SITE 210
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT ACT_SITE 234
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT ACT_SITE 306
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT ACT_SITE 309
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT ACT_SITE 332
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
FT ACT_SITE 341
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01816"
SQ SEQUENCE 356 AA; 41323 MW; D559AA5C09E336A9 CRC64;
MRRELLLERI DKLKATMPWY ILEYYQSKLA VPYSFTTLYE YLKEYDRFFN WVLESGITDA
SHIAEIPLSV LENMSKKDME AFILYLRERP LLNANTTQNG VSQTTINRTL SALSSLYKYL
TEEVENEQGE PYFYRNVMKK VATKKKKETL AARAENIKQK LFLGDETEEF LQYIDTEYPK
KLSNRALSSF NKNKERDLAI IALLLASGVR LSEAVNLDLK DINLKMMVIE VTRKGGKRDS
VNVAAFAKPY LEEYLSIRIK RYKAEKTDTA FFLTEYRGIP NRIDASSVEK MVAKYSEDFK
VRVTPHKLRH TLATRLYDAT KSQVLVSHQL GHASTQVTDL YTHIVNDEQK NALDKL