ID   XER_PSEAI               Reviewed;         427 AA.
AC   Q9F771;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Putative tyrosine recombinase XerC {ECO:0000305};
GN   Name=xerC {ECO:0000312|EMBL:AAG02084.1};
OS   Pseudomonas aeruginosa.
OG   Plasmid pKLC102.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SG17M;
RX   PubMed=11021913; DOI=10.1099/00221287-146-10-2365;
RA   Kiewitz C., Larbig K., Klockgether J., Weinel C., Tuemmler B.;
RT   "Monitoring genome evolution ex vivo: reversible chromosomal integration of
RT   a 106 kb plasmid at two tRNA(Lys) gene loci in sequential Pseudomonas
RT   aeruginosa airway isolates.";
RL   Microbiology 146:2365-2373(2000).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC       the cutting and rejoining of the recombining DNA molecules.
CC       {ECO:0000250|UniProtKB:P0A8P8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- MISCELLANEOUS: In contrast to other XerC proteins, it has a longer C-
CC       terminal part. {ECO:0000305}.
CC   -!- MISCELLANEOUS: It is found in the pKLC102 plasmid, which can integrate
CC       the bacterial chromosome at the att site of the pilA hypervariable
CC       region.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; AF285416; AAG02084.1; -; Genomic_DNA.
DR   RefSeq; WP_003158137.1; NZ_UGUJ01000005.1.
DR   RefSeq; YP_006960522.1; NC_019202.1.
DR   AlphaFoldDB; Q9F771; -.
DR   SMR; Q9F771; -.
DR   eggNOG; COG4973; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   DNA integration; DNA recombination; DNA-binding; Plasmid.
FT   CHAIN           1..427
FT                   /note="Putative tyrosine recombinase XerC"
FT                   /id="PRO_0000095352"
FT   DOMAIN          1..81
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          116..305
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   REGION          323..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        156
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        183
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        256
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        259
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        283
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        292
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   427 AA;  48138 MW;  830637E70A0420A7 CRC64;
     MTPQQLTEEY IFAHDLREAS AKIYRAATKA LLKHFGPTAT VQDVDHRAVL GWRRKVLEQG
     LSKRSWNTYS NHLRTIWGYA IEHELVTHSQ VNPFRKTTVI PPRRASKTVA AEAILRARSW
     LSMQVGAERC TGDRARITPA WFWLCTFEVF YYTGIRLNAL LCIRKRDIDW DNQLILIRGE
     TEKTHKEFVV PITEGLVPHL SRLLQEAEKA GFADDDQLFN VNRFSPHYKS KTMNSDQVEA
     MYRKLTEKVG VRMTPHRFRH TLATDLMKAP ERNIHLTKCL LNHSNIQTTM SYIEADYDHM
     RAVLHARSLA QGALENVRKV DYSGSPQASA KPKPCGQPLA RVGEVPPPEA RTEPSEPREH
     TQETGIQRGP TSWEAEAVPQ PPDTFEQSVL FTLMAQHLSN RAATASAVPA ATSGSGGRGS
     AARDSLA