ID   XGEA_ASPCL              Reviewed;         241 AA.
AC   A1CRJ0;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Probable xyloglucan-specific endo-beta-1,4-glucanase A;
DE            EC=3.2.1.151;
DE   AltName: Full=Xyloglucanase A;
DE   AltName: Full=Xyloglucanendohydrolase A;
DE   Flags: Precursor;
GN   Name=xgeA; ORFNames=ACLA_029940;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Catalyzes endohydrolysis of 1,4-beta-D-glucosidic linkages in
CC       xyloglucan with retention of the beta-configuration of the glycosyl
CC       residues. Specific for xyloglucan and does not hydrolyze other cell
CC       wall components (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=xyloglucan + H2O = xyloglucan oligosaccharides.; EC=3.2.1.151;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 12 (cellulase H) family.
CC       {ECO:0000305}.
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DR   EMBL; DS027059; EAW08261.1; -; Genomic_DNA.
DR   RefSeq; XP_001269687.1; XM_001269686.1.
DR   AlphaFoldDB; A1CRJ0; -.
DR   SMR; A1CRJ0; -.
DR   CAZy; GH12; Glycoside Hydrolase Family 12.
DR   EnsemblFungi; EAW08261; EAW08261; ACLA_029940.
DR   GeneID; 4701658; -.
DR   KEGG; act:ACLA_029940; -.
DR   VEuPathDB; FungiDB:ACLA_029940; -.
DR   eggNOG; ENOG502S675; Eukaryota.
DR   HOGENOM; CLU_051064_0_1_1; -.
DR   OMA; WAGGNIH; -.
DR   OrthoDB; 1236368at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008810; F:cellulase activity; IEA:InterPro.
DR   GO; GO:0033946; F:xyloglucan-specific endo-beta-1,4-glucanase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.180; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR013319; GH11/12.
DR   InterPro; IPR002594; GH12.
DR   PANTHER; PTHR34002; PTHR34002; 1.
DR   Pfam; PF01670; Glyco_hydro_12; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cell wall biogenesis/degradation; Glycosidase;
KW   Hydrolase; Polysaccharide degradation; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..241
FT                   /note="Probable xyloglucan-specific endo-beta-1,4-glucanase
FT                   A"
FT                   /id="PRO_0000394069"
SQ   SEQUENCE   241 AA;  25618 MW;  A157B55B1CF038BC CRC64;
     MKFNLALALS LTVATAEAAT ELCKQWDSII EGNFIVYNNL WGQGNADDGG HQCTTVKSIS
     GDTVVWSTEW AWSGGPGQVK SYANAALQFT PTTLSSVSSI DSTWKWRDSY TGSDIVANVA
     YDMFLSSSAT GSEEYEIMVW LAALGGAGPI SSTGSPIATP TINGVQWDLY LGPNGAMQVY
     SFVAPSSTEN FAGDMKGFID YLTSEQGLSK DLYLLDVQAG TEPFSGSDAV LTVSEYSVNL
     A